Results 111 to 120 of about 619,769 (292)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Legal determinants for running a parish based economic activity
Kościół i Prawo, 2013 Celem artykułu było ukazanie uwarunkowań prawnych parafii w zakresie wykonywania działalności gospodarczej. Parafia na mocy art. 32 i 20 Konstytucji RP, art. 4 ust. 2 Konkordatu oraz art. 55 ust. 3 ustawy o stosunku Państwa do Kościoła Katolickiego w RP,
Paweł Kaleta
doaj
Foreword: Revisiting Gilson and Kraakman’s Efficiency Story [PDF]
, 2003 Gilson and Kraakman\u27s ‘Mechanisms of Market Efficiency’ is part of the canon of modem corporate law scholarship, one of a handful of articles that has profoundly influenced the way we think about the field.
Langevoort, Donald C.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
Scientific ReportsThis retrospective study developed an automated algorithm for 3D segmentation of adipose tissue and paravertebral muscle on chest CT using artificial intelligence (AI) and assessed its feasibility.
Akinori Hata +20 more
doaj +1 more source
Now: Music from the musicals 1975 - 2018 [PDF]
, 2018 Musical Theatre performance at The Meteor Theatre Gwen is an opera singer and is joined for an evening of song, by special guests; Courteney Mayall, Alex Pelham-Waerea, Scot Hall, Hannah MacFarlane and Michaela Gilling Accompanied by the incomparable ...
Lyon, Gwen, Sidwell, David
core