Results 111 to 120 of about 641,970 (337)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Die Herausbildung des biblischen Kanons im antiken Judentum und im frühen Christentum [PDF]

open access: yes, 2017
Starting with the observation that the canon of the Bible differs among the Christian denominations (Lutheran, Reformed, Roman Catholic), and that definitive decisions on the canon were not made before the 16th century, the author gives a brief account ...
Frey, Jörg
core  

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

Efficacy of compressed sensing and deep learning reconstruction for adult female pelvic MRI at 1.5 T

open access: yesEuropean Radiology Experimental
Background We aimed to determine the capabilities of compressed sensing (CS) and deep learning reconstruction (DLR) with those of conventional parallel imaging (PI) for improving image quality while reducing examination time on female pelvic 1.5-T ...
Takahiro Ueda   +9 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

open access: yesFEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Automatic tricuspid valve annulus extraction and measurement from computed tomography images

open access: yesInformatics in Medicine Unlocked
Background and objective: Tricuspid regurgitation (TR) is one of the most common forms of valvular heart diseases. The morphological information of the tricuspid valve annulus (TVA) is critical in treatment planning for TR. It is necessary to extract the
Gakuto Aoyama   +9 more
doaj   +1 more source

Localization of an experimental ecological unit in the Maradi region of Nigeria [PDF]

open access: yes
A detailed topographical and geomorphological description of a specific ecological unit in the Maradi region of the Sahel in the Niger Republic is presented. Sandy structures are classified into active dunes and covered dunes and an extensives vocabulary
Canon, L., Chapelle, A. M., Mainguet, M.
core   +1 more source

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