Results 161 to 170 of about 444,205 (224)

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

In vitro production significantly reduces metabolic differences among bovine embryos. [PDF]

Metabolomics
Laloë D, Gatien J, Dupuy C, Archilla C, Laffont L, Ruffini S, Canon E, Le Bourhis D, Deloche MC, Dubois O, Leguienne B, Nadal-Desbarats L, Calderari S, Escouflaire C, Desnoes O, Schibler L, Salvetti P, Duranthon V.   +17 more
europepmc   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds. [PDF]

J Parasitol Res
Sifontes-Rodríguez S, Meneses-Gómez S, Escalona-Montaño AR, Sánchez-Almaraz DA, Pérez-Olvera O, Cañón Rosas AR, Cruz Bautista PZ, Aguirre-García MM.   +7 more
europepmc   +1 more source

Presidential Signing Statements Under the Bush Administration: A Threat to Checks and Balances and the Rule of Law?: Hearing Before the H. Comm. on the Judiciary, 110th Cong., Jan. 31, 2007 (Statement of Nicholas Quinn Rosenkranz, Prof. of Law, Geo. U. L. Center) [PDF]

, 2007
Rosenkranz, Nicholas Quinn
core   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Ultra-high spatial resolution at photon-counting computed tomography: technical insights and sustainable applications in cardiothoracic imaging. [PDF]

Eur Radiol Exp
Occhipinti M, Clemente A, De Gori C, Positano V, Neglia D, Celi S, Meloni A, Berti S, Cademartiri F.   +8 more
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Multicenter, Multinational, and Multivendor Validation of an Artificial Intelligence Application for Acute Cervical Spine Fracture Detection on CT. [PDF]

Diagnostics (Basel)
Sung J, Chang PD, Ayobi A, Cotena M, Roca-Sogorb M, Jang J, Chow DS, Chaibi Y.   +7 more
europepmc   +1 more source