Results 61 to 70 of about 183,993 (251)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Canonical correlation analysis of main breeding traits for Landrace
浙江大学学报. 农业与生命科学版, 2000 The analysis of canonical correlation for 14 traits in 3 groups was carried out in the study. The growth and development traits composed of 4 traits, body size 6 traits and fat thickness and appearance 4 traits.
XU Ning-ying +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Detection for gene-gene co-association via kernel canonical correlation analysis
BMC Genetics, 2012 Background Currently, most methods for detecting gene-gene interaction (GGI) in genomewide association studies (GWASs) are limited in their use of single nucleotide polymorphism (SNP) as the unit of association.
Yuan Zhongshang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Türkiye Tarımsal Araştırmalar Dergisi, 2020 This study was conducted to estimate the relationships between the ultrasonic measurements and carcass characteristics of Akkaraman lambs at different intensive feeding periods with a multivariate correlation (canonical).
Yasin ALTAY +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A whitening approach to probabilistic canonical correlation analysis for omics data integration
BMC Bioinformatics, 2019 Background Canonical correlation analysis (CCA) is a classic statistical tool for investigating complex multivariate data. Correspondingly, it has found many diverse applications, ranging from molecular biology and medicine to social science and finance.
Takoua Jendoubi, Korbinian Strimmer
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A survey on canonical correlation analysis based multi-view learning
智能科学与技术学报, 2022 Multi-view learning (MVL) is a strategy for fusing data from different sources or subsets.Canonical correlation analysis (CCA) is very important in MVL, whose main idea is to maximize the correlation of different views.The traditional CCA can only ...
Chenfeng GUO, Dongrui WU
doaj