Results 91 to 100 of about 396,548 (332)

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair.

PLoS ONE, 2011
Canonical WNT signaling plays multiple roles in lung organogenesis and repair by regulating early progenitor cell fates: investigation has been enhanced by canonical Wnt reporter mice, TOPGAL, BATGAL and Axin2(LacZ).
Denise Al Alam, Melissa Green, Reza Tabatabai Irani, Sara Parsa, Soula Danopoulos, Frederic G Sala, Jonathan Branch, Elie El Agha, Caterina Tiozzo, Robert Voswinckel, Edwin C Jesudason, David Warburton, Saverio Bellusci   +12 more
doaj   +1 more source

Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice

Frontiers in Cell and Developmental Biology, 2020
The R-spondin (RSPO) family of proteins potentiate canonical WNT/β-catenin signaling and may provide a mechanism to fine-tune the strength of canonical WNT signaling.
Yong-Ri Jin, Xiang Hua Han, Katsuhiko Nishimori, Dan Ben-Avraham, Youn Jeong Oh, Jae-won Shim, Jae-won Shim, Jeong Kyo Yoon, Jeong Kyo Yoon   +8 more
doaj   +1 more source

In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions

Cells, 2022
Canonical Wnt signaling is involved in skeletal muscle cell biology. The exact way in which this pathway exerts its contribution to myogenesis or neuromuscular junctions (NMJ) is a matter of debate.
Lea Gessler, Christopher Kurtek, Mira Merholz, Yongzhi Jian, Said Hashemolhosseini   +4 more
doaj   +1 more source

Micronized dehydrated human amniotic membrane inhibits canonical Wnt/β-Catenin signaling pathway in cytokine stimulated human articular chondrocytes and downregulates hypertrophic, catabolic and inflammatory factors [PDF]

, 2021
Chi‐Li Chung, Michelle Massee, Thomas J. Koob   +2 more
openalex   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer

PPAR Research, 2017
In both colon cancer and type 2 diabetes, metabolic changes induced by upregulation of the Wnt/beta-catenin signaling and downregulation of peroxisome proliferator-activated receptor gamma (PPAR gamma) may help account for the frequent association of ...
Y. Lecarpentier, V. Claes, Alexandre Vallée, J. Hébert   +3 more
semanticscholar   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling

Nature Communications
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory.
Xing Yang, Haibo Xu, Xu Yang, Hui Wang, Li Zou, Qin Yang, Xiaopeng Qi, Li Li, Hongxia Duan, Xiyun Yan, Nai Yang Fu, Jing Tan, Zongliu Hou, Baowei Jiao   +13 more
doaj   +1 more source

Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors

OncoTarget, 2017
The liver provides vital metabolic, exocrine and endocrine functions in the body as such pathological conditions of the liver lead to high morbidity and mortality. The liver is highly regenerative and contains facultative stem cells that become activated
Jiaming Fan, Q. Wei, J. Liao, Y. Zou, D. Song, Dong-mei Xiong, Chao Ma, Xue Hu, X. Qu, Liqun Chen, Li Li, Yichun Yu, Xinyi Yu, Zhicai Zhang, Chen Zhao, Z. Zeng, Ruyi Zhang, Shujuan Yan, Tingting Wu, Xing-ye Wu, Y. Shu, J. Lei, Yasha Li, Wenwen Zhang, R. Haydon, H. Luu, A. Huang, T. He, Hua Tang   +28 more
semanticscholar   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source