Results 271 to 280 of about 75,163 (297)

Non-canonical WNT signalling in the lung [PDF]

Journal of Biochemistry, 2015
The role of WNT signalling in metazoan organogenesis has been a topic of widespread interest. In the lung, while the role of canonical WNT signalling has been examined in some detail by multiple studies, the non-canonical WNT signalling has received limited attention.
Saverio Bellusci, Parviz Minoo, Zea Borok   +2 more
exaly   +3 more sources

Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology [PDF]

International Journal of Molecular Sciences, 2021
The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of
Janja Marc, Marc Janja
exaly   +2 more sources

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The Canonical Wnt Signaling Pathway in Autism

CNS & Neurological Disorders - Drug Targets, 2014
Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the
Yinghua, Zhang, Xiangshan, Yuan, Zhongping, Wang, Ruixi, Li   +3 more
openaire   +2 more sources

The role of the Wnt canonical signaling in neurodegenerative diseases

Life Sciences, 2016
The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly regulated, which activation results
Emanuela Mazzon, Placido Bramanti
exaly   +3 more sources

A Wnt canon orchestrating osteoblastogenesis

Trends in Cell Biology, 2006
Several transcription factors have been identified that control the differentiation of osteoblasts; however, relatively little is known about the signaling pathways involved in regulating the differentiation process. Recently, the canonical Wnt-beta-catenin pathway has been implicated in osteoblastogenesis.
openaire   +2 more sources

p120-catenin in canonical Wnt signaling

Critical Reviews in Biochemistry and Molecular Biology, 2017
Canonical Wnt signaling controls β-catenin protein stabilization, its translocation to the nucleus and the activation of β-catenin/Tcf-4-dependent transcription. In this review, we revise and discuss the recent results describing actions of p120-catenin in different phases of this pathway. More specifically, we comment its involvement in four different
Mireia, Duñach, Beatriz, Del Valle-Pérez, Antonio, García de Herreros   +2 more
openaire   +2 more sources

Wnt signaling through canonical and non-canonical pathways: Recent progress

Growth Factors, 2005
The Wnt-beta-catenin pathway regulates cell adhesion, morphology, proliferation, migration and structural remodeling. The aspects of the canonical and non-canonical pathways are reviewed here. The major components of this network are the Wnt ligands which bind to frizzled receptors at the cell surface.
Randall Widelitz
exaly   +3 more sources

The canonical Wnt pathway in embryonic axis polarity

Seminars in Cell & Developmental Biology, 2006
The canonical Wnt pathway plays crucial roles in multiple developmental processes, including in axis specification. Throughout the animal kingdom, this pathway has been reported to drive patterning of axes as different as the animal-vegetal axis in echinoderms to the dorsal-ventral axis in vertebrates.
Croce, Jenifer, Mcclay, David
openaire   +3 more sources

Beyond canonical: The Wnt and β-catenin story

Science Signaling, 2016
Regulation by Wnts and β-catenin reveals the pitfalls in canonical thinking.
Randall T, Moon, Nancy R, Gough
openaire   +2 more sources

Non-canonical Wnt signaling pathways in hematopoiesis

Immunologic Research, 2009
Hematopoietic stem cells (HSCs) are a rare population of cells that are responsible for life-long generation of blood cells of all lineages. In order to maintain their numbers, HSCs must establish a balance between the opposing cell fates of self-renewal and initiation of hematopoietic differentiation.
Kathleen, Kokolus, Michael J, Nemeth
openaire   +2 more sources