Results 281 to 290 of about 396,548 (332)

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan   +8 more
wiley   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang   +4 more
wiley   +1 more source

Meflin/ISLR is a meningeal cell‐specific marker involved in the development of meninges and meningioma progression

open access: yesBrain Pathology, Volume 36, Issue 2, March 2026.
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki   +13 more
wiley   +1 more source

IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury

open access: yesLiver International, Volume 46, Issue 3, March 2026.
ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou   +12 more
wiley   +1 more source

Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma. [PDF]

open access: yesCancer Med
Meagher M   +13 more
europepmc   +1 more source

Genomic Insights Into the Use of Green Tea (Camellia sinensis) as a Functional Feed Additive in Sustainable Aquaculture

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 1, February 2026.
ABSTRACT Aquaculture is the fastest‐growing sector of animal food production, yet it faces increasing challenges in maintaining fish health and sustainability due to the widespread use of antibiotics and synthetic feed additives. Green tea (Camellia sinensis), a natural source of polyphenols and bioactive compounds, has gained attention as a functional
Nahida Akter   +8 more
wiley   +1 more source

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