Results 61 to 70 of about 396,548 (332)
Wnt Moves Beyond the Canon [PDF]
Science, 2008 A secreted protein associated with the metastasis of a melanoma harnesses cell adhesion proteins and the cytoskeleton to direct cell motility.
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FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5
Scientific Reports, 2017 The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during canonical and non-
Prameet Kaur +5 more
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A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
Oncogenesis, 2021 The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron +9 more
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Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells
Frontiers in Bioscience-Landmark, 2022 Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy.
Dymphna Margriet Ouwens +12 more
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THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA [PDF]
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 2019 It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis.To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma.The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1 ...
OLIVEIRA,Levindo Alves de +6 more
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
B-1 cells and B-1 cell precursors prompt different responses to Wnt signaling.
PLoS ONE, 2018 Recently several studies demonstrated a role for the Wnt pathway in lymphocyte development and self-renewal of hematopoietic stem cells (HSCs). B-1 cells constitute a separate lineage of B lymphocytes, originating during fetal hematopoiesis, expressing ...
Lika Osugui +5 more
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Nature Communications, 2018 Satellite cells are crucial for skeletal muscle regeneration, but the molecular mechanisms regulating satellite cells are not entirely understood. Here, we show that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a newly identified
Kuo Zhang +17 more
semanticscholar +1 more source
Non‐canonical wnt signals antagonize and canonical wnt signals promote cell proliferation in early kidney development [PDF]
Developmental Dynamics, 2011 AbstractCanonical and non‐canonical wnt signals often have opposed roles. In this report, we use developing Xenopus embryos to demonstrate a novel anti‐proliferative role for non‐canonical wnt signals in the very earliest stages of kidney development.
Kyle E, McCoy +2 more
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