Results 71 to 80 of about 396,548 (332)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

Frontiers in Endocrinology, 2019
Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could
Heidrun Vethe, Luiza Ghila, Magnus Berle, Magnus Berle, Laurence Hoareau, Øystein A. Haaland, Hanne Scholz, Hanne Scholz, Joao A. Paulo, Simona Chera, Helge Ræder, Helge Ræder   +11 more
doaj   +1 more source

Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway

Journal of experimental & clinical cancer research : CR, 2019
Numerous studies have presented that curcumin could have a positive effect in the prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that curcumin could decreases tumor growth and invasion by acting on both chronic ...
Alexandre Vallée, Y. Lecarpentier, J. Vallée   +2 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Metabolism, one of the most conserved features across all domains of life, is interwoven with cellular signaling networks and the posttranslational modification state of proteins.
L. Albrecht, M. H. Bui, E. D. De Robertis   +2 more
semanticscholar   +1 more source

Functional conservation of Nematostella Wnts in canonical and noncanonical Wnt-signaling [PDF]

Biology Open, 2011
Summary Cnidarians surprise by the completeness of Wnt gene subfamilies (11) expressed in an overlapping pattern along the anterior-posterior axis. While the functional conservation of canonical Wnt-signaling components in cnidarian gastrulation and organizer formation is evident, a role of Nematostella Wnts in noncanonical Wnt-signaling
T Rigo-Watermeier, B Kraft, M Ritthaler, V Wallkamm, T Holstein, D Wedlich   +5 more
openaire   +3 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Sex determination involves antagonistic interactions between the testis-determining (SRY-SOX9-FGF9) and ovary-promoting (RSPO1-WNT/β-catenin-FOXL2) pathways, but the underlying molecular mechanisms remain unclear.
Abigail S Harris, P. Siggers, Silvia Corrochano, N. Warr, D. Sagar, D. Grimes, Makoto Suzuki, R. Burdine, Feng Cong, B. Koo, H. Clevers, I. Stévant, S. Nef, S. Wells, R. Brauner, Bochra Ben Rhouma, N. Belguith, C. Eozenou, J. Bignon-Topalovic, A. Bashamboo, K. McElreavey, A. Greenfield   +21 more
semanticscholar   +1 more source

Canonical Wnt Signaling: An Unexpected New Player [PDF]

Developmental Cell, 2006
Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of beta-catenin via an unresolved mechanism. A recent study in Genes & Development introduces a new player and deepens our understanding of this signaling relay that plays pivotal roles during embryogenesis and tumorigenesis.
openaire   +2 more sources

Pax6 Expressed in Osteocytes Inhibits Canonical Wnt Signaling [PDF]

Molecules and Cells, 2013
The transcription factor Pax6, which belongs to the paired box-containing gene family, regulates developmental processes, especially in the eyes, central nervous tissues and craniofacial structures. However, the role of Pax6 in bone has never been studied exclusively.
Jung, HS, Lim, SK, Jami, J, Gadi, J, Lee, MJ, Kim, EJ, Lee, MJ, Kim, HH   +7 more
openaire   +4 more sources