Results 81 to 90 of about 396,548 (332)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling

Cell Reports, 2019
Summary: Wnt signaling pathways direct key physiological decisions in development. Here, we establish a role for a pleckstrin homology domain-containing protein, PLEKHA4, as a modulator of signaling strength in Wnt-receiving cells.
Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin   +8 more
doaj   +1 more source

Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling

Frontiers in Oncology, 2022
WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent ...
Kinjal Shah, Kinjal Shah, Julhash U. Kazi, Julhash U. Kazi   +3 more
doaj   +1 more source

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer.

Cancer Research, 2018
Macropinocytosis has emerged as an important pathway of protein acquisition in cancer cells, particularly in tumors with activated Ras such as pancreatic and colon cancer.
Gil Redelman-Sidi, A. Binyamin, Isabella M. Gaeta, Wilhelm Palm, C. Thompson, P. Romesser, S. Lowe, Mukta Bagul, John G Doench, D. Root, M. Glickman   +10 more
semanticscholar   +1 more source

Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling [PDF]

Journal of Biological Chemistry, 2013
Dishevelled (Dvl) proteins are intracellular effectors of Wnt signaling that have essential roles in both canonical and noncanonical Wnt pathways. It has long been known that Wnts stimulate Dvl phosphorylation, but relatively little is known about its functional significance.
González Sancho, José Manuel, Endo, Yoshimi, Abrahams, Cristina L., Takigawa, Yutaka, Baljinnyam, Bolormaa, Lee, Kyung Ho, Lee, Kyung S., Rubin, Jeffrey S., Brown, Anthony M.C   +8 more
openaire   +4 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Expression of Wnt signaling components during Xenopus pronephros development. [PDF]

PLoS ONE, 2011
The formation of the vertebrate kidney is tightly regulated and relies on multiple evolutionarily conserved inductive events. These are present in the complex metanephric kidney of higher vertebrates, but also in the more primitive pronephric kidney ...
Bo Zhang, Uyen Tran, Oliver Wessely
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development

PLoS Biology, 2018
The Wnt family of secreted proteins has been proposed to play a conserved role in early specification of the bilaterian anteroposterior (A/P) axis.
S. Darras, Jens H. Fritzenwanker, K. Uhlinger, E. Farrelly, Ariel M. Pani, Imogen A. Hurley, R. Norris, Michelle Osovitz, M. Terasaki, Mike Wu, Jochanan Aronowicz, M. Kirschner, J. Gerhart, C. Lowe   +13 more
semanticscholar   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source