, 2016 The scanning model for eukaryotic mRNA translation initiation states that the small ribosomal subunit, along with initiation factors, binds at the cap structure at the 5' end of the mRNA and scans the 5' untranslated region (5'UTR) until an initiation ...
Lacerda, Rafaela +2 more
core +1 more source
Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract
Advanced Robotics Research, EarlyView.We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis +7 more
wiley +1 more source
Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response. [PDF]
Nucleic Acids Res, 2022 Slobodin B +11 more
europepmc +1 more source
Human AGO1 5’UTR mediates an elF4G-enhanced but cap-independent mechanism of translation initiation
Argonaute 1 (AGO1) is an essential effector in RNA-mediated gene silencing pathways. It regulates developmental control and stem cell maintenance, and is related to tumourigenesis. Such functions suggest its expression must be tightly regulated and, most
Lacerda, Rafaela +2 more
core
Auditory–Tactile Congruence for Synthesis of Adaptive Pain Expressions in RoboPatients
Advanced Robotics Research, EarlyView.In this work, we explore auditory–tactile congruence for synthesizing adaptive vocal pain expressions in robopatients. Using a robopatient platform that integrates vocal pain sounds with palpation forces, we conducted 7680 trials across 20 participants.
Saitarun Nadipineni +4 more
wiley +1 more source
Correction to 'The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation'. [PDF]
Nucleic Acids Res, 2022 Ramos H +10 more
europepmc +1 more source
Miniaturized Magnetic Tip Design for Endoluminal Vine Robot Navigation
Advanced Robotics Research, EarlyView.A magnetic tip mount is designed for a miniaturized 7 mm soft‐growing vine robot to enable wireless magnetic steering and onboard imaging, while preserving a 3 mm working channel. The internal–external ring magnets design balances magnetic attachment with low eversion pressure. Experiments demonstrate ±90° steering, 34 mm bending radius, and successful
Andrea Yanez Trujillo +4 more
wiley +1 more source
The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation. [PDF]
Nucleic Acids Res, 2022 Ramos H +10 more
europepmc +1 more source
Advanced Robotics Research, EarlyView.Intelligent Sky Guardians (InSkyGuard) is introduced as a four‐drone swarm that autonomously detects, tracks, and safely captures rogue drones using a coordinated net system. Computer vision and leader–follower control architecture enable synchronized enclosure, while integrated failsafes enhance system reliability. Validated through closed‐environment
Joshua Hastings +6 more
wiley +1 more source
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source