Results 141 to 150 of about 71,269 (263)
Advanced Science, EarlyView.This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong +7 more
wiley +1 more source
The involvement of cap-independent mRNA translation in cell fate decisions
, 2014 During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism.
Morrison, J. Kaitlin
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Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse
Advanced Science, EarlyView.We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang +7 more
wiley +1 more source
Personalized Network‐Guided Neuromodulation Enhances Human Working Memory
Advanced Science, EarlyView.A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan +13 more
wiley +1 more source
Corrigendum to: Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice. [PDF]
Aging Cell, 2023 europepmc +1 more source
The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection [PDF]
, 2011 As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two
McMahon, Robert
core
, 1995 To investigate which hairpin structures within the 5′ untranslated region of hepatitis C virus (HCV) are necessary for cap-independent translation, mutants were constructed that lack one or more hairpin structures.
Lemon, Stanley +13 more
core +1 more source
Advanced Science, EarlyView.Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu +14 more
wiley +1 more source
The role of UPF1 cap-independent translation in colorectal cancer
Colorectal cancer (CRC) is one of the deadliest diseases worldwide with projections pointing towards an increase for the next two decades. Translation dysregulation of many genes contributes to CRC development, and here we are studying the role of ...
Lacerda, Rafaela +4 more
core
The growing relevance of cap-independent translation initiation in cancer-related genes
, 2012 Twomainmechanisms for eukaryotic initiation of protein synthesis have been described – the canonical cap-dependent and the alternative cap-independent.
ALBERTO INGA +7 more
core