Results 131 to 140 of about 11,911,049 (290)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A relational approach to energy poverty: a case for policy toward equalising capability deployment, not energy consumption

open access: yes, 2018
In this presentation, I will build upon a recent publication to propose a brief account on how to think more just energy transitions by complementing the capability theory with input from Cornelius Castoriadis, a Greek-French thinker (1922-1997). To this
Workshop on “Energy Justice and the capability approach”   +1 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A capability approach to the analysis of rural households' wellbeing in Nigeria [PDF]

open access: yes
Rural households in Nigeria have been characterized as poor, and with little opportunity for development. Many studies have equated poverty with well being, however empirical literature on well being is less researched.
Adepoju, Temitayo A., Oni, Omobowale A.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Re-conceptualising sustainable development on the basis of the capability approach: A model and its difficulties [PDF]

open access: yes
This paper sketches a re-conceptualisation of sustainable development (SD) on the basis of the capability approach (CA). The notion sustainable development was developed as a compromise in a political process and has been re-interpreted (some say ...
Leßmann, Ortrud, Rauschmayer, Felix
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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