Results 131 to 140 of about 2,190,448 (297)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Implications of equipping a DC-8-61 fleet with RNAV/two-segment approach avionics [PDF]

open access: yes
Due to the costs of implementing two-segment approaches with special purpose computers, and the fact that such systems rely on special ground equipment not generally in use today, it is useful to consider the possibility of adding a two-segment approach ...
Anderson, E. B.
core   +1 more source

Learning from their mistakes - an online approach to evaluate teacher education students\u27 numeracy capability [PDF]

open access: yes, 2019
Teachers’ numeracy capability is essential for student learning in the classroom and important across all subject areas, not only within mathematics.
Colbourn, Adelle   +3 more
core   +1 more source

A Capability Approach to worker dignity under Algorithmic Management. [PDF]

open access: yesEthics Inf Technol, 2022
Lamers L, Meijerink J, Jansen G, Boon M.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

'Capacitas': Contract Law and the Institutional Preconditions of a Market Economy [PDF]

open access: yes
Capacity may be defined as a status conferred by law for the purpose of empowering persons to participate in the operations of a market economy. This paper argues that because of the confining influence of the classical private law of the nineteenth ...
Simon Deakin
core  

Introduction: Justice and Disadvantages during Childhood: What Does the Capability Approach Have to Offer? [PDF]

open access: yes, 2016
Justice for children and during childhood and the particular political, social and moral status of children has long been a neglected issue in ethics, and in social and political philosophy. The application of general, adult-
Cabezas, Mar   +2 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy