The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The capability approach to intergenerational justice: A survey [PDF]
The politically influential idea of sustainable development is closely tied to the concept of inter- and intragenerational justice without clarifying these concepts and their relationship.
Leßmann, Ortrud +3 more
core
Objection or Obstacle: Applying Amartya Sen's Capability Approach to the Conscientious Refusal of Emergency Contraception. [PDF]
Int J Fem Approaches Bioeth, 2022 Moore CM.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The capability dilemma in operational poverty assessment [PDF]
This paper compares the standard economic welfare approach to poverty measurement to the empirical approaches proposed in the capability literature under the special focus of their suitability for operational poverty assessment, i.e.
Stephan Klasen +2 more
core
Application of the capability approach to Indigenous People's health and well-being: protocol for a mixed-methods scoping review. [PDF]
BMJ Open, 2022 van der Boor C +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A Capability Approach to worker dignity under Algorithmic Management. [PDF]
Ethics Inf Technol, 2022 Lamers L, Meijerink J, Jansen G, Boon M.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Sustainable competitive advantage in maternal and child health institutions: a dynamic capability approach. [PDF]
Ann Oper Res, 2022 Yuan H, Ferreira FAF.
europepmc +1 more source