Results 101 to 110 of about 2,918,690 (278)

Improving Early Detection of Dementia: Extra Trees-Based Classification Model Using Inter-Relation-Based Features and K-Means Synthetic Minority Oversampling Technique

Big Data and Cognitive Computing
The early detection of dementia, a condition affecting both individuals and society, is essential for its effective management. However, reliance on advanced laboratory tests and specialized expertise limits accessibility, hindering timely diagnosis.
Yanawut Chaiyo, Worasak Rueangsirarak, Georgi Hristov, Punnarumol Temdee   +3 more
doaj   +1 more source

Perspectives on the Training of Chinese Primary Health Care Physicians to Reduce Chronic Illnesses and Their Burden

Frontiers in Public Health, 2019
This paper is a commentary on the training of Chinese Primary Health Care Doctors to reduce chronic illness and its burden. First, we will consider the policy position of the Chinese government concerning the development of a competent and enlarged ...
Wenmin Sun, Yang Li, Yiting Hu, Yiting Hu, Xin Rao, Xin Rao, Xingzhi Xu, Xingzhi Xu, Colette Joy Browning, Colette Joy Browning, Colette Joy Browning, Shane Andrew Thomas, Shane Andrew Thomas   +12 more
doaj   +1 more source

The Challenge of African Youth Unemployment [PDF]

, 2016
This Occasional Paper submits that Africa’s youth unemployment requires long-term, deliberate, well-targeted, and coordinated interventions. Addressing it requires integrated, comprehensive, and long-term approaches to rural development that provide an ...
African Capacity Building Foundation
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

National Evaluation of the Capacity Building Programme in English Local Government: Overall Final Report [PDF]

, 2008
This report is one of a series of outputs from the National Evaluation of the Capacity Building Programme for local government in England (CBP), undertaken by a team of researchers at the Policy Research Institute (PRI) at Leeds Metropolitan University ...
Dowson, L, Halliday, S, Kelsey, S, Nunn, A, Purcell, M, Stevens, A   +5 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Detection and comparison of SARS-CoV-2 antibody produced in naturally infected patients and vaccinated individuals in Addis Ababa, Ethiopia: multicenter cross-sectional study

Virology Journal
Background Natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vaccination triggers antibody production against key viral antigens.
Chala Bashea, Addisu Gize, Tadesse Lejisa, Demiraw Bikila, Betselot Zerihun, Feyissa Challa, Daniel Melese, Alganesh Gebreyohanns, Kasahun Gorems, Solomon Ali, Gadissa Bedada Hundie, Habteyes Hailu Tola, Wondewosen Tsegaye   +12 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Why Engage? Understanding the Incentive to Build Nonprofit Capacity [PDF]

, 2005
The literature regarding nonprofit capacity building is expanding as funders, infrastructure support organizations, researchers, and others interested in strengthening the sector work to develop a better understanding of how to build organizational ...
Angela Bies, Judith Millesen
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source