Results 71 to 80 of about 2,918,690 (278)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Criminal Law (Amendment) Act, 2013: Will it ensure women’s safety in public spaces?
Space and Culture, India, 2013 The horrific gang-rape and the subsequent murder of Nirbyaya (fearless) in December 2012, impelled the Government of India to pass the Criminal Law (Amendment) Act, 2013. The key aim of this article is to review this Act in the light of women's safety in
Rituparna Bhattacharyya
doaj +1 more source
Building Capacity for Domestic Resource Mobilization: The Role of the Civil Society [PDF]
, 2016 The policy brief by the African Capacity Building Foundation (ACBF) highlights that while it is widely agreed that domestic resource mobilization is the way to go, the 2015 Africa Capacity Report shows that this may not be achieved because of one missing
African Capacity Building Foundation
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Jàmbá, 2009 The conditions prevailing in the world, where fast growing populations are coupled with rapidly expanding urbanization and a general increase in poverty levels, are greatly aggravating the disaster risks and vulnerabilities of a large part of the world’s
Mmaphaka Tau
doaj +1 more source
African Union Agenda 2063: African Critical Technical Skills: Key Capacity Dimensions Needed for the First 10 Years of Agenda 2063 [PDF]
, 2016 This publication produced by the African Capacity Building Foundation (ACBF) in conjuction with the African Union Commission (AUC) observes that the single biggest challenge to ownership of Africa’s development agenda and management of its key ...
African Capacity Building Foundation
core +1 more source
Building the capacity to solve complex health challenges in Sub-Saharan Africa : CARTA’s multidisciplinary PhD training [PDF]
, 2016 Objectives: To develop a curriculum (Joint Advanced Seminars- JAS) that produced PhD fellows who understood that health is an outcome of multiple determinants within complex environments and that approaches from a range of disciplines is required to ...
A McVicar +25 more
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Building Agricultural Capacity in Newfoundland and Labrador [PDF]
, 2012 Newfoundland and Labrador faces considerable challenges in maintaining a consistent and reliable food supply. The lack of locally produced food has resulted in the province’s dependency on imported foods.
Quinlin, A. James
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source