Results 81 to 90 of about 2,918,690 (278)
BMC Infectious DiseasesBackground The Uganda ministry of Health recommends frequent blood glucose monitoring for the first six months on dolutegravir, in people with HIV (PWH) having pre-diabetes mellitus (pre-DM). We sought to determine if indeed PWH with pre-diabetes started
Frank Mulindwa +10 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A Theoretical Field Study within the Discipline of Sociology of Education
Zanco Journal of Humanity SciencesLanguage is seen as a dynamic component of social culture and is ever evolving. From a societal perspective, language has more purposes than just conveying information.
Chnar Saad Abdulla
doaj +1 more source
Creating a Foursquare Communications Platform: Easy Steps to Build the Communications Capacity of Your Grantees [PDF]
, 2010 Spitfire Strategies specializes in building the capacity of foundations and their grantees to plan and implement highly successful communications strategies.
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Building Institutional Capacity for Development [PDF]
, 2009 {Excerpt} Every day, we are reminded of the changes needed for economic and social progress, but not that institutions are the channels through which such changes can happen. We would do well to consider what is meant by (and can be accomplished through)
Serrat, Olivier
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Evaluation Capacity Building: Funder Initiatives to Strengthen Grantee Evaluation Capacity and Practice [PDF]
, 2011 Innovation Network has a wealth of experience as an evaluation capacity builder. One way we often provide ECB services is to a group of grantees. Over the years we have provided funder-sponsored ECB services to a number of grantee cohorts.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
International Journal of Disaster Risk Science, 2017 This preliminary study examines the definition problem and challenges of climate forecasting and disaster responses associated with the El Niño costero (coastal) of 2017, which developed rapidly with no warning and had catastrophic effects in Peru.
Ivan J. Ramírez, Fernando Briones
doaj +1 more source