Results 51 to 60 of about 477,421 (267)

Use of EMG-Derived Slope Coefficient for Determination of Muscle Functional Capacity [PDF]

Journal of Orthopaedic & Sports Physical Therapy, 1983
The purpose of this study was to determine if the slope coefficient for the linear relationship between EMG voltage time integral and submaximal isometric contractions of the vastus medialis muscle could be used as a means for evaluating the muscle's functional capacity.
F G, Delacerda, C W, Couch, M, McElwain
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Tree-based estimation of canopy water storage capacity and direct throughfall coefficient of Cupressus arizonica Green. [PDF]

تحقیقات جنگل و صنوبر ایران, 2014
The aim of this study was to estimate the individual tree-based 1) canopy water storage capacity (S), 2)  ratio of mean evaporation rate from the wet canopy to the mean rainfall intensity () by the Pereira method, and 3) direct throughfall coefficient (p)
Seyyed Mohammad Moein Sadeghi, Pedram Attarod, Thomas Grant Pypker, Vilma Bayramzadeh   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Parameter Analysis of Pile Foundation Bearing Characteristics Based on Pore Water Pressure Using Rapid Load Test

Infrastructures
A novel approach for determining the bearing capacity of pile foundations using rapid load testing is suggested to rectify the inaccuracies arising from the presumption of a constant damping coefficient and excess pore water pressure during the ...
Jing-Jie Su, Xue-Liang Zhao, Qing Guo, Wei-Ming Gong, Yu-Chen Wang, Tong-Xing Zeng   +5 more
doaj   +1 more source

Analysis of Two-Layered Journal Bearing Lubricated with Ferrofluid

MATEC Web of Conferences, 2014
The present study investigates the load capacity and friction coefficient for a two-layered journal bearing lubricated with ferrofluid. A modified Reynolds equation for a two-layered ferrofluid is derived using displaced infinitely long wire magnetic ...
Rao T. V. V. L. N., Rani A. M. A., Nagarajan T., Hashim F. M.   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Research on the mixed discharge capacity of new hydraulic flap gate

工程科学与技术, 2013
:Using a conceptual model test to explore new type of hydraulic flap gate mixed discharge capacity of weir and orifice flow, getting the relationship of opening degree, flow, and the water level, proposed a method of calculation the mixed discharge ...
Lei Ming-Hui, Nie Ruihua
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source