Results 91 to 100 of about 1,085,206 (268)

Adverse sequelae of the COVID-19 pandemic on mental healthcare in six low- and middle-income countries (MASC): a mixed-methods study with lessons for the future

BMJ Open
Objectives The Mental health care: Adverse Sequelae of COVID-19 study aimed to (1) compare the consequences of the COVID-19 pandemic for mental health services and people with pre-existing mental health conditions (MHCs) in six low- and middle-income ...
Heidi Lempp, Katherine Sorsdahl, Atalay Alem, Charlotte Hanlon, Wubalem Fekadu, Oye Gureje, Nicole Votruba, Graham Thornicroft, Awoke Mihretu, Rubén Alvarado, Ezra Susser, Anuprabha Wickramasinghe, Elaine Brohan, Azeb Asaminew Alemu, Olatunde Olayinka Ayinde, Adekunle Adesola, Thandi Davies, Lucy Jalagania, Nino Makhashvili, Eleni Misganaw, Maria Milenova, Tamar Mujirishvili, Olha Myshakivska, Irina Pinchuk, Camila Solis-Araya, Gonzalo Soto-Brandt, Olga Toro-Devia, Shehan Williams   +27 more
doaj   +1 more source

Research on capacity region of Gaussian degraded relay broadcast channel

上海师范大学学报. 自然科学版, 2017
Considering the relay broadcast channel (RBC),the transmitter communicates with two receivers with the assistance of a relay.Based on degradation orders among the relay and the receiver outputs,three types of physically degraded RBCs (PDRBCs) model are ...
Ma Yingying, Wang Ke, Wu Youlong
doaj   +1 more source

On Capacity Region of Wiretap Networks

CoRR, 2012
In this paper we consider the problem of secure network coding where an adversary has access to an unknown subset of links chosen from a known collection of links subsets. We study the capacity region of such networks, commonly called "wiretap networks", subject to weak and strong secrecy constraints, and consider both zero-error and asymptotically ...
Shirin Jalali, Tracey Ho
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Regions and the search for spatial justice: a question of capacity?

Regional Studies
Peer ...
Rhys Jones, Sami Moisio
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source