Results 111 to 120 of about 7,419,611 (261)
Frontiers in Health ServicesSomalia's National Transformation Plan (NTP) 2025–2029 presents an ambitious health-reform agenda centred on maternal and child health, workforce development, health-system strengthening, regulation, financing, digitalisation, and emergency preparedness.
Nor Haji Osman +14 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Absorptive Capacity in Practice-Based Innovation Activities: the Case of Lahti Region, Finland [PDF]
As a consequence of for example agglomeration economies, features such as good reputation and highly-skilled labour force tend to accumulate in university regions.
Vesa Harmaakorpi +2 more
core
A purposeful community: the region as a focus for community capacity building
, 2014 A key defining feature of successful and sustainable communities is a clearly articulated sense of purpose. This is crucial in helping community members to identify who they are and what their communities are seeking to achieve.
Danaher, Patrick Alan +1 more
core +1 more source
A review of reservoir sedimentation and water storage losses in the Ethiopian highlands
Discover SustainabilityReservoirs are vital sources of water for agriculture, industry, and domestic uses. However, in the Ethiopian highlands, reservoir sedimentation is a growing challenge for dam operators as huge amounts of sediments accumulate behind dams, reducing ...
Sisay Asres +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Africa Capacity Report 2014: Capacity Imperatives for Regional Integration in Africa
, 2014 The Africa Capacity Report (ACR) and its supporting indicators offer inputs for decisions on what to finance to develop capacity. Most countries are doing well on their policy environments and having processes in place to implement policies.
African Capacity Building Foundation (19289548)
core +1 more source