Results 11 to 20 of about 67,411 (205)

A phase IB and randomised phase IIA trial of CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases: CARBON trial results

Journal of Bone Oncology, 2022
Background: Approximately 70% of patients with metastatic breast cancer (MBC) develop bone metastases. Despite advances in systemic treatment options and the use of bone targeted agents in the management of bone metastases to reduce skeletal morbidity ...
Matthew Winter, Rob Coleman, Jessica Kendall, Carlo Palmieri, Chris Twelves, Sacha Howell, Iain MacPherson, Caroline Wilson, Kash Purohit, Jacqui Gath, Christine Taylor, Richard Eastell, Geraldine Murden, Sarah R. Brown, Emma Rathbone, Janet Brown   +15 more
doaj   +1 more source

In vitro anti-proliferative effect of capecitabine (Xeloda) combined with mocetinostat (MGCD0103) in 4T1 breast cancer cell line by immunoblotting [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Mouse breast cancer cell line 4T1 can accurately mimic the response to immune receptors and targeting therapeutic agents. Combined therapy has emerged as an important strategy with reduced side effects and maximum therapeutic effect ...
Hacer Kaya Cakır, Onur Eroglu
doaj   +1 more source

Randomized Study of Temozolomide or Temozolomide and Capecitabine in Patients With Advanced Pancreatic Neuroendocrine Tumors (ECOG-ACRIN E2211)

Journal of Clinical Oncology, 2022
PURPOSE Patients with advanced pancreatic neuroendocrine tumors (NETs) have few treatment options that yield objective responses. Retrospective and small prospective studies suggest that capecitabine and temozolomide are associated with high response ...
P. Kunz, N. Graham, P. Catalano, H. Nimeiri, G. Fisher, T. Longacre, Carlos J. Suarez, B. Martin, James C. Yao, M. Kulke, A. Hendifar, J. Shanks, M. Shah, M. Zalupski, E. Schmulbach, D. Reidy‐Lagunes, J. Strosberg, P. O'Dwyer, P. O'Dwyer, A. Benson   +19 more
semanticscholar   +1 more source

Case Report: Various Abnormalities in Lipid and Glucose Metabolism Induced by Capecitabine

Frontiers in Oncology, 2021
Capecitabine has been used for the treatment of various types of tumors. The rare side effects induced by capecitabine have been reported as hypertriglyceridemia, acute pancreatitis associated with hypertriglyceridemia and hypertriglyceridemia ...
Takatoshi Anno, Tomoki Yamatsuji, Koichi Tomoda, Shuhei Nakanishi, Hideaki Kaneto   +4 more
doaj   +1 more source

Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial.

The Lancet Gastroenterology and Hepatology, 2022
BACKGROUND Patients with borderline resectable pancreatic ductal adenocarcinoma have relatively low resection rates and poor survival despite the use of adjuvant chemotherapy.
P. Ghaneh, D. Palmer, S. Cicconi, R. Jackson, C. Halloran, C. Rawcliffe, R. Sripadam, S. Mukherjee, Z. Soonawalla, J. Wadsley, A. Al-mukhtar, E. Dickson, J. Graham, Long R. Jiao, H. Wasan, I. Tait, A. Prachalias, P. Ross, J. Valle, D. A. O’Reilly, B. Al-Sarireh, S. Gwynne, Irfan Ahmed, K. Connolly, K. Yim, D. Cunningham, T. Armstrong, C. Archer, K. Roberts, Yuk Ting Ma, C. Springfeld, C. Tjaden, T. Hackert, M. Büchler, J. Neoptolemos   +34 more
semanticscholar   +1 more source

The Clinical Value of Chemotherapy Combined With Capecitabine in Triple-Negative Breast Cancer—A Meta-Analysis

Frontiers in Pharmacology, 2021
Purpose: Triple-negative breast cancer (TNBC) is the most dangerous subtype of breast cancer with high rates of metastasis and recurrence. The efficacy of capecitabine in chemotherapy for TNBC is still controversial. This study evaluated the efficacy and
Zilin Zhang, Kai Ma, Jing Li, Yeneng Guan, Chaobo Yang, Aqin Yan, Hongda Zhu   +6 more
doaj   +1 more source

Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases

JAMA Oncology, 2022
Key Points Question Can tucatinib, trastuzumab, and capecitabine provide systemic and intracranial benefit for patients with ERBB2 (HER2)-positive metastatic breast cancer and brain metastases?
N. Lin, R. Murthy, V. Abramson, C. Anders, T. Bachelot, P. Bedard, V. Borges, D. Cameron, L. Carey, A. J. Chien, G. Curigliano, M. DiGiovanna, K. Gelmon, G. Hortobagyi, S. Hurvitz, I. Krop, S. Loi, S. Loibl, V. Mueller, Mafalda Oliveira, E. Paplomata, M. Pegram, D. Slamon, A. Zelnak, J. Ramos, W. Feng, Eric P. Winer   +26 more
semanticscholar   +1 more source

Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer (“METRIC”): a randomized multicenter study

npj Breast Cancer, 2021
The METRIC study (NCT#0199733) explored a novel antibody–drug conjugate, glembatumumab vedotin (GV), targeting gpNMB that is overexpressed in ~40% of patients with triple-negative breast cancer (TNBC) and associated with poor prognosis.
Linda T. Vahdat, Peter Schmid, Andres Forero-Torres, Kimberly Blackwell, Melinda L. Telli, Michelle Melisko, Volker Möbus, Javier Cortes, Alberto J. Montero, Cynthia Ma, Rita Nanda, Gail S. Wright, Yi He, Thomas Hawthorne, Rebecca G. Bagley, Abdel-Baset Halim, Christopher D. Turner, Denise A. Yardley   +17 more
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Concomitant Administration of Capecitabine and Folate Supplements: Need to Encourage Medication Reconciliation

Pharmaceuticals, 2022
Hand-Foot syndrome (HFS) and diarrhoea are dose-limiting Adverse Drug Reactions (ADRs) of capecitabine-based chemotherapy. Four polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) gene, encoding the DPD enzyme responsible for the metabolism of ...
Berenice Stefanelli, Carmine Sellitto, Emanuela De Bellis, Martina Torsiello, Nicola Bertini, Angelo Maria Pezzullo, Graziamaria Corbi, Francesco Sabbatino, Stefano Pepe, Angela Tesse, Valeria Conti, Amelia Filippelli   +11 more
doaj   +1 more source

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

Pharmacology Research & Perspectives, 2022
Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model.
James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm   +8 more
doaj   +1 more source