Results 251 to 260 of about 721,706 (356)

The mechanisms in glucose metabolism of aging hippocampus

open access: yesIbrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He   +6 more
wiley   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

open access: yesInternational Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto   +21 more
wiley   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

open access: yesInternational Journal of Cancer, EarlyView.
What's New? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff   +13 more
wiley   +1 more source

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

open access: yesiMetaOmics, EarlyView.
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen   +7 more
wiley   +1 more source

Capillary Electrophoresis as a Complementary Analytical Tool for the Separation and Detection of Nanoplastic Particles. [PDF]

open access: yesAnal Chem
Adelantado C   +5 more
europepmc   +1 more source

Advances in Isothermal Amplification for the Diagnosis of Tuberculosis

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
The emergence of isothermal amplification techniques presents a promising solution for tuberculosis (TB) diagnosis. These methods are attractive due to their simplicity, speed, and ability to perform without specialised equipment, which could make them suitable for low‐resource settings.
Nuttapon Jirakittiwut   +1 more
wiley   +1 more source

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