Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method [PDF]
Frontiers in ImmunologyMessenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs our
Kanghyun Choi +36 more
doaj +6 more sources
A novel and safe SmartCap® SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans [PDF]
Frontiers in ImmunologyWe have developed a 5′-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5′-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied.
Rachel Kim +23 more
doaj +3 more sources
Treatment Outcomes and Prognostic Factors of Direct Pulp Capping in Permanent Teeth: A Systematic Review and Meta-Analysis [PDF]
European Endodontic JournalThis study aimed to evaluate the overall treatment outcomes of direct pulp capping in permanent teeth and investigate the prognostic factors. MEDLINE via Ovid, EMBASE, PubMed, Cochrane Library, and manual search methods were used to select the included ...
Nattawut Prasertsuksom +3 more
doaj +3 more sources
Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid–azapeptoid hybrid library [PDF]
Bioorganic & Medicinal Chemistry, 2016 A potent and selective inhibitor of platelet-activating factor acetylhydrolase 1B2 (PAFAH1B2) is described. The compound was derived by improvement of a modest affinity primary hit isolated from the screening of a bead-displayed peptoid-azapeptoid hybrid library tethered to an oxadiazolone 'warhead'.
Bani Kanta Sarma +2 more
openaire +3 more sources
Furan-Conjugated Tripeptides as Potent Antitumor Drugs
Biomolecules, 2020 Cervical cancer is among the leading causes of death in women. Chemotherapy options available for cervical cancer include highly cytotoxic drugs such as taxol, cisplatin, 5-florouracil, and doxorubicin, which are not specific.
Hunain Ali +9 more
doaj +2 more sources
Virus Research, 2013 Capsid protein (Cap), the only structural protein of porcine circovirus 2 (PCV2), is involved in the host protective response and is a target for vaccine development. To find a rapid and easy way to fully map the antigenic epitopes of Cap, purified Cap-specific polyclonal antibodies were used to screen a random heptapeptide phage display library. After
Meng, Ge +6 more
openaire +3 more sources
Marine Drugs, 2014 Pure compound screening has previously identified the indolglyoxy lamidospermidine ascidian metabolites didemnidine A and B (2 and 3) to be weak growth inhibitors of Trypanosoma brucei rhodesiense (IC50 59 and 44 μM, respectively) and Plasmodium ...
Jiayi Wang, Marcel Kaiser, Brent R. Copp
doaj +2 more sources
Interfacial-Redox-Induced Tuning of Superconductivity in YBa2Cu3O7-δ. [PDF]
, 2019 Solid-state ionic approaches for modifying ion distributions in getter/oxide heterostructures offer exciting potentials to control material properties.
Arenholz, Elke +15 more
core +2 more sources
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]
, 2020 Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P. +18 more
core +1 more source
Active Site Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly [PDF]
, 2017 Xylan-degrading enzymes are crucial for the deconstruction of hemicellulosic biomass, making the hydrolysis products available for various industrial applications such as the production of biofuel.
de Kruijff, Goswinus H. M. +6 more
core +1 more source