Development of a screening platform for the identification of macrocyclic splicing inhibitors [PDF]
, 2023 Protein-RNA interactions are substance of research of the last decades and are yet to be fully explored. Interactions of RNA-binding proteins (RBPs) with RNA are found in a plethora of fundamental biological processes such as transcription, splicing ...
Nowacki-Hansen, Jessica
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Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]
, 2008 Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Naomi Walsh +12 more
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Computational approaches for investigating protein-ligand interactions - towards an in-depth understanding of the dengue virus methyltransferase [PDF]
, 2013 Interactions between proteins and their ligands play crucial roles in many biological processes, such as metabolism, signaling, transport, regulation or molecular recognition. Understanding the molecular basis of protein-ligand interactions is thus of
Schmidt, Tobias Benjamin
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Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor.
, 2011 The RNA guanylyltransferase (GTase) is involved in the synthesis of the (m7)Gppp-RNA cap structure found at the 5' end of eukaryotic mRNAs. GTases are members of the covalent nucleotidyl transferase superfamily, which also includes DNA and RNA ligases ...
Simon Despins +3 more
core +2 more sources
ACCU Core Sampling/Storage Device for VOC Analysis [PDF]
, 2007 The Accu Core sampler system consists of alternating cylindrical clear acrylic sections and one-inch cylindrical stainless steel sections arranged in clear shrink wrap.
Schabron, John F. +2 more
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Contemporary management of deep caries in primary teeth: a systematic review and meta-analysis
, 2022 Purpose: To systematically evaluate the available evidence regarding contemporary management of deep caries in vital primary teeth. This review was carried out to facilitate the development of European Academy of Paediatric Dentistry (EAPD) guidelines on
Stratigaki, E. +5 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
, 2009 Recently a first genome-wide analysis of translational regulation using prokaryotic species had been performed which revealed that regulation of translational efficiency plays an important role in haloarchaea.
Jörg Soppa +5 more
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Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors [PDF]
, 2021 The COVID-19 pandemic has clearly brought the healthcare systems worldwide to a breaking point, along with devastating socioeconomic consequences.
Yazdi, AK +20 more
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