Results 11 to 20 of about 25,065,735 (222)

Anticipated regret to increase uptake of colorectal cancer screening (ARTICS):a randomised controlled trial [PDF]

, 2015
Screening is important for early detection of colorectal cancer. Our aim was to determine whether a simple anticipated regret (AR) intervention could increase uptake of colorectal cancer screening. A randomised controlled trial of a simple, questionnaire-
Brownlee, Linda A., Steele, Robert J. C., O'Carroll, Ronan E., Steele, Robert, Chambers, Julie A., Chambers, Julie, Brownlee, Linda, Libby, Gillian, Steele, Robert J.C., O'Carroll, Ronan   +9 more
core   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +2 more sources

Recommendations for a colorectal cancer screening programme in Ireland [PDF]

, 2008
In April 2007, the National Cancer Screening Service Board established an expert advisory group to study the medical and scientific evidence concerning screening for colorectal cancer and to make recommendations to the Board about the potential benefits ...
NCSS Expert Advisory Group on Colorectal Cancer Screening
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source