Results 21 to 30 of about 84,218 (260)

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose? [PDF]

, 2016
As our understanding of the impact of specific molecular properties on applications in discovery-based disciplines improves, the extent to which published synthetic methods meet (or do not meet) desirable criteria is ever clearer. Herein, we show how the
Atack, Beisken, Bertrand, Bickerton, Brown, Brown, Chambers, Clarke, Collins, Collins, Collins, Colomer, Cooper, Craven, Davis, Davis, Deeming, Doveston, Druzhenko, El Khatib, Firth, Foley, Gandy, Garcia-Castro, Geoghegan, Goldberg, Isidro-Llobet, Karawajczyk, Kingwell, Lamberth, Li, Lipinski, Lipinski, Lipkus, Lovering, Lowe, Luescher, Luescher, Luescher, Lüthy, Michaudel, Moon, Morley, Murray, Nadin, Pajouhesh, Petersen, Rao, Rawling, Ritchie, Ruddigkeit, Ryabukhin, Siau, Storr, Toutov, Vo, Wager, Wager, Walters, Wild, Wolfe, Wu, Xie, Yasukawa   +63 more
core   +1 more source

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

bioRxiv, 2021
Lassa virus (LASV) belongs to the Old World genus Mammarenavirus, family Arenaviridae, and order Bunyavirales. Arenavirus contains a segmented negative-sense RNA genome, which is in line with the bunyavirus and orthomyxoviruses.
Xiao-Yan Lan, Yueli Zhang, Yang Liu, Jiao Guo, X. Jia, Mengmeng Zhang, Junyuan Cao, Gengfu Xiao, Yu Guo, W. Wang   +9 more
semanticscholar   +1 more source

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. [PDF]

, 2016
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumour cells and repress translation of specific messenger RNAs.
Floor, Stephen N, Ingolia, Nicholas T, Iwasaki, Shintaro   +2 more
core   +1 more source

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans [PDF]

, 2018
Background: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic
Artal Sanz, Marta, Askjaer, Peter, Baumeister, Ralf, Erinjeri, Annmary Paul, González Hernández, Sara, Hernando Rodríguez, Blanca, Millar, Val, Muñoz, Manuel J., Olmedo López, María, Rodríguez Palero, María Jesús, Schulze, Bettina   +10 more
core   +1 more source

Antitumor activity of an anti-CD98 antibody. [PDF]

, 2015
CD98 is expressed on several tissue types and specifically upregulated on fast-cycling cells undergoing clonal expansion. Various solid (e.g., nonsmall cell lung carcinoma) as well as hematological malignancies (e.g., acute myeloid leukemia) overexpress ...
Cairns, Belinda, Cantor, Joseph M, Chinn, Lawrence, Duey, Dana, Ginsberg, Mark H, H van der Horst, Edward, Hayes, Gregory M, Levashova, Zoia, Lippincott, John, Tran, Hoang, Velilla, Timothy, Zachwieja, Joseph   +11 more
core   +1 more source

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]

, 2017
The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao, Fang, Mei-Juan, Gao, Xiang, Shao, Rui, Wang, Hui-Ru, Wu, Jun, Wu, Zhen, Xue, Yu-Hua, Yu, Diao, Zhou, Qiang   +9 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. [PDF]

, 2019
During autophagy, actin filament networks move and remodel cellular membranes to form autophagosomes that enclose and metabolize cytoplasmic contents. Two actin regulators, WHAMM and JMY, participate in autophagosome formation, but the signals linking ...
Axe, Cooper, Coutts, Coutts, Coyle, Dayel, Demonacos, Firat-Karalar, Graef, Hu, Jahreiss, Kaiser, Kast, Klionsky, Koronakis, Li, Mathiowetz, Mi, Okrut, Padrick, Padrick, Palmgren, Pankiv, Pankiv, Papinski, Quinlan, Quinlan, R. Dyche Mullins, Ran, Rohatgi, Rohatgi, Schlüter, Shibutani, Shikama, Sun, Urbanek, Welch, Xiaohua Hu, Yamamoto, Zhao, Zuchero   +40 more
core   +2 more sources

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Fluorescent turn-on probes for wash-free mRNA imaging via covalent site-specific enzymatic labeling. [PDF]

, 2017
Investigating the many roles RNA plays in cellular regulation and function has increased demand for tools to explore RNA tracking and localization within cells.
Alexander, Seth C, Devaraj, Neal K, Zhou, Cun Yu   +2 more
core   +2 more sources