Results 21 to 30 of about 95,314 (260)

In Silico Identification of the Potential Natural Inhibitors of SARS-CoV-2 Guanine-N7 Methyltransferase.

RESEARCH RESULTS IN BIOMEDICINE, 2020
The outbreak of the COVID-19 pandemic caused by the SARS-CoV-2 has triggered intense scientific research into the possible therapeutic strategies that can combat the ravaging disease.
A. Rowaiye, O. Onuh, J. Oladimeji-Salami, D. Bur, M. Njoku, N. Ifedilichukwu, C. John, O. Binuyo, Faith Udo Pius   +8 more
semanticscholar   +1 more source

Serum Stabilities of Short Tryptophan- and Arginine-Rich Antimicrobial Peptide Analogs

PLoS ONE, 2010
Background Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization.
L. T. Nguyen, Johnny K. Chau, Nicole A. Perry, L. de Boer, S. Zaat, H. Vogel   +5 more
semanticscholar   +1 more source

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans [PDF]

, 2018
Background: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic
Artal Sanz, Marta, Askjaer, Peter, Baumeister, Ralf, Erinjeri, Annmary Paul, González Hernández, Sara, Hernando Rodríguez, Blanca, Millar, Val, Muñoz, Manuel J., Olmedo López, María, Rodríguez Palero, María Jesús, Schulze, Bettina   +10 more
core   +1 more source

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]

, 2017
The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao, Fang, Mei-Juan, Gao, Xiang, Shao, Rui, Wang, Hui-Ru, Wu, Jun, Wu, Zhen, Xue, Yu-Hua, Yu, Diao, Zhou, Qiang   +9 more
core   +2 more sources

Screening and identification of Lassa virus endonuclease-targeting inhibitors from a fragment-based drug discovery library.

Antiviral Research, 2021
Lassa virus (LASV) belongs to the Old World genus Mammarenavirus, family Arenaviridae, and order Bunyavirales. Arenavirus contains a segmented negative-sense RNA genome, which is in line with the bunyavirus and orthomyxoviruses.
Xiao-Yan Lan, Yueli Zhang, X. Jia, Si-Yu Dong, Yang Liu, Mengmeng Zhang, Jiao Guo, Junyuan Cao, Yu Guo, Gengfu Xiao, Wen Wang   +10 more
semanticscholar   +1 more source

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose? [PDF]

, 2016
As our understanding of the impact of specific molecular properties on applications in discovery-based disciplines improves, the extent to which published synthetic methods meet (or do not meet) desirable criteria is ever clearer. Herein, we show how the
Atack, Beisken, Bertrand, Bickerton, Brown, Brown, Chambers, Clarke, Collins, Collins, Collins, Colomer, Cooper, Craven, Davis, Davis, Deeming, Doveston, Druzhenko, El Khatib, Firth, Foley, Gandy, Garcia-Castro, Geoghegan, Goldberg, Isidro-Llobet, Karawajczyk, Kingwell, Lamberth, Li, Lipinski, Lipinski, Lipkus, Lovering, Lowe, Luescher, Luescher, Luescher, Lüthy, Michaudel, Moon, Morley, Murray, Nadin, Pajouhesh, Petersen, Rao, Rawling, Ritchie, Ruddigkeit, Ryabukhin, Siau, Storr, Toutov, Vo, Wager, Wager, Walters, Wild, Wolfe, Wu, Xie, Yasukawa   +63 more
core   +1 more source

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. [PDF]

, 2016
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumour cells and repress translation of specific messenger RNAs.
Floor, Stephen N, Ingolia, Nicholas T, Iwasaki, Shintaro   +2 more
core   +1 more source

Structural basis of IL-23 antagonism by an Alphabody protein scaffold [PDF]

, 2014
Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics.
Bloch, Yehudi, Deroo, Sabrina, Desmet, Johan, Devreese, Bart, Henderikx, Paula, Hettmann, Thore, Lasters, Ignace, Lorent, Eric, Loverix, Stefan, Savvides, Savvas, Somers, Klaartje, Vandenbroucke, Karen, Verstraete, Kenneth, Wen, Yurong   +13 more
core   +1 more source

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

bioRxiv, 2021
Lassa virus (LASV) belongs to the Old World genus Mammarenavirus, family Arenaviridae, and order Bunyavirales. Arenavirus contains a segmented negative-sense RNA genome, which is in line with the bunyavirus and orthomyxoviruses.
Xiao-Yan Lan, Yueli Zhang, Yang Liu, Jiao Guo, X. Jia, Mengmeng Zhang, Junyuan Cao, Gengfu Xiao, Yu Guo, W. Wang   +9 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source