Results 1 to 10 of about 925 (119)

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH [PDF]

Open Biology, 2023
G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation ...
Tim Schulte, Marc D. Panas, Xiao Han, Lucy Williams, Nancy Kedersha, Jonas Simon Fleck, Timothy J. C. Tan, Xaquin Castro Dopico, Anders Olsson, Ainhoa Moliner Morro, Leo Hanke, Johan Nilvebrant, Kim Anh Giang, Per-Åke Nygren, Paul Anderson, Adnane Achour, Gerald M. McInerney   +16 more
doaj   +5 more sources

Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer [PDF]

Journal of Translational Medicine, 2023
Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment will develop new strategies to ...
Wenbo Yang, Hongze Chen, Guanqun Li, Tao Zhang, Yuhang Sui, Liwei Liu, Jisheng Hu, Gang Wang, Hua Chen, Yongwei Wang, Xina Li, Hongtao Tan, Rui Kong, Bei Sun, Le Li   +14 more
doaj   +6 more sources

Radiopharmaceutical application of TRK-950, an anti-CAPRIN-1 therapeutic antibody [PDF]

Journal of Cancer Research and Clinical Oncology
Purpose Tumor imaging or therapy using cancer specific carriers combined with a radioisotope has huge potential. In radiopharmaceutical development, it is important to ensure target specificity and minimal binding to normal tissues for both tumor ...
Yuki Majima, David Kryza, Mitsuaki Sanada, Jacqueline Sidi-Boumedine, Patrick Mehlen, Benjamin Gibert, Jean-Yves Blay, Fumiyoshi Okano   +7 more
doaj   +5 more sources

Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP [PDF]

Journal of Translational Medicine, 2023
Background Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is implicated in cancer cell proliferation and tumorigenesis; however, its role in the development of esophageal carcinoma (ESCA) has not been examined.
Yan Gao, Lingling Yuan, Changbin Ke, Zhijun Pei, Xiaobo Liu, Ruimin Wu, Xueyan Kui, Yanmin Zhang   +7 more
doaj   +6 more sources

Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts? [PDF]

eJournal of Oral Maxillofacial Research
Objectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about ...
Nelli Yildirimyan, Mehmet Ali Altay, İrem Hicran Özbudak   +2 more
doaj   +7 more sources

Role of caprin-1 in carcinogenesis. [PDF]

Oncol Lett, 2019
RNA-binding proteins serve an essential role in post-transcriptional gene regulation. Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is an RNA-binding protein that participates in the regulation of cell cycle control-associated genes.
Yang ZS, Qing H, Gui H, Luo J, Dai LJ, Wang B.   +5 more
europepmc   +6 more sources

Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950. [PDF]

Cancer Res Commun, 2023
Specific targets for cancer treatment are highly desirable, but still remain to be discovered. While previous reports suggested that CAPRIN-1 localizes in the cytoplasm, here we now show that part of this molecule is strongly expressed on the cell membrane surface in most solid cancers, but not normal tissues. Notably, the membrane expression of CAPRIN-
Okano F, Saito T, Minamida Y, Kobayashi S, Ido T, Miyauchi Y, Wasai U, Akazawa D, Kume M, Ishibashi M, Jiang K, Aicher A, Heeschen C, Yonehara T.   +13 more
europepmc   +5 more sources

Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions. [PDF]

J Proteome Res, 2021
AbstractCytoplasmic stress granules (SGs) are dynamic non-membranous foci containing translationally arrested mRNA and RNA binding proteins that form in response to a variety of cellular stressors. SGs may evolve into the cytoplasmic inclusions observed in many neurodegenerative diseases.
Vu L, Ghosh A, Tran C, Tebung WA, Sidibé H, Garcia-Mansfield K, David-Dirgo V, Sharma R, Pirrotte P, Bowser R, Vande Velde C.   +10 more
europepmc   +7 more sources

MicroRNA-181a Functions as an Oncogene in Gastric Cancer by Targeting Caprin-1 [PDF]

Frontiers in Pharmacology, 2019
MicroRNA-181a (miRNA-181a) is a multifaceted miRNA implicated in various cellular processes, particularly in cell fate determination and cellular invasion.
Qiang Lu, Yanchun Chen, Yanchun Chen, Dan Sun, Shukun Wang, Kang Ding, Meiyi Liu, Yan Zhang, Yujuan Miao, Huancai Liu, Fenghua Zhou, Fenghua Zhou   +11 more
doaj   +5 more sources

Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway [PDF]

Cancer Cell International, 2021
Background Epithelial–mesenchymal transition (EMT) promotes migration, invasion, and metastasis of hepatocellular carcinoma (HCC) cells. The molecular mechanisms behind EMT and metastasis in HCC remain unclear.
Hong-Lin Luo, Tao Luo, Jun-Jie Liu, Fei-Xiang Wu, Tao Bai, Chao Ou, Jie Chen, Le-Qun Li, Jian-Hong Zhong   +8 more
doaj   +5 more sources