Figure S8 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>Mechanism of the TRK-950 antitumor effect in mouse model</p>
Fumiyoshi Okano +13 more
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Figure S3 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>CAPRIN-1 is not expressed on the cell surface of hematologic cancer cells.</p>
Fumiyoshi Okano +13 more
+4 more sources
Table S1 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>Clinical, pathological findings in the toxicity study in Cynomolgus Monkeys</p>
Fumiyoshi Okano +13 more
+4 more sources
, 2023 <div><p>Specific targets for cancer treatment are highly desirable, but still remain to be discovered. While previous reports suggested that CAPRIN-1 localizes in the cytoplasm, here we now show that part of this molecule is strongly expressed on the cell membrane surface in most solid cancers, but not normal tissues.
Fumiyoshi Okano +13 more
openalex +2 more sources
Crystal structure of a dimerization domain of human Caprin-1: insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1. [PDF]
Acta Crystallogr D Struct Biol, 2016 Caprin-1 plays roles in many important biological processes, including cellular proliferation, innate immune response, stress response and synaptic plasticity. Caprin-1 has been implicated in several human diseases, including osteosarcoma, breast cancer, viral infection, hearing loss and neurodegenerative disorders.
Wu Y, Zhu J, Huang X, Du Z.
europepmc +4 more sources
, 2023 <p>Toxicokinetics of TRK-950 in Cynomolgus Monkeys</p>
Fumiyoshi Okano +13 more
openalex +2 more sources
Figure S9 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
, 2023 <p>ADCC and ADCP activity of TRK-950 via human and monkey immune cells</p>
Fumiyoshi Okano +13 more
+4 more sources
Absence of Caprin-1 Results in Defects in Cellular Proliferation [PDF]
The Journal of Immunology, 2005 Abstract Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is a cytoplasmic phosphoprotein that is the prototype of a novel family of highly conserved proteins. Its levels, except in the brain, are tightly correlated with cellular proliferation.
Bin Wang +2 more
openalex +4 more sources
Emerging evidence of targeting non-oncogenic drivers for gastric cancer: Claudin18.2 and beyond [PDF]
Therapeutic Advances in Medical OncologyHuman epidermal growth factor receptor 2 was the first successful molecular target in treating gastric cancer, marking a significant milestone for targeted therapies.
Kazumasa Yamamoto +2 more
doaj +2 more sources