Results 31 to 40 of about 925 (119)

Figure S5 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950

, 2023
<p>Correlation of CAPRIN-1 expression levels on the cell surface with tumor cell growth in vivo or in vitro.</p>
Fumiyoshi Okano, Takanori Saito, Yoshitaka Minamida, Shinichi Kobayashi, Takayoshi Ido, Yasushi Miyauchi, Ukei Wasai, Daisuke Akazawa, Masahiko Kume, Masaki Ishibashi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tetsu Yonehara   +13 more
openalex   +2 more sources

Caprin‐1 Promotes Cellular Uptake of Nucleic Acids with Backbone and Sequence Discrimination [PDF]

Helvetica Chimica Acta, 2019
AbstractThe cellular delivery of oligonucleotides has been a major obstacle in the development of therapeutic antisense agents. PNAs (Peptide Nucleic Acid) are unique in providing a modular peptidic backbone that is amenable to structural and charge modulation.
Valentina Galli, Kalyan K. Sadhu, Daniela Masi, Jacques Saarbach, Aurélien Roux, Nicolas Winssinger   +5 more
openalex   +3 more sources

Figure S2 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950

, 2023
<p>CAPRIN-1 correlated to the cell proliferation and viability.</p>
Fumiyoshi Okano, Takanori Saito, Yoshitaka Minamida, Shinichi Kobayashi, Takayoshi Ido, Yasushi Miyauchi, Ukei Wasai, Daisuke Akazawa, Masahiko Kume, Masaki Ishibashi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tetsu Yonehara   +13 more
openalex   +2 more sources

The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [PDF]

Journal of Virology
Stress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay.
Ayisha A. Lavender, Oreoluwa Solanke, Hsin-Yao Tang, Hannah E. Peck, Daryll Vanover, Philip J. Santangelo, Margo A. Brinton   +6 more
doaj   +2 more sources

Embryonic thermal conditioning and post-hatch heat challenge alter hypothalamic expression of genes related to appetite, thermoregulation, and stress modulation in broiler chicks [PDF]

Frontiers in Physiology
The objective of this study was to determine the effects of an acute heat challenge on day 4 post-hatch on the transcriptome of several brain nuclei associated with thermal regulation, stress, and appetite. These included the paraventricular nucleus (PVN)
Reagan Vaughan, Usman Sulaiman, Annalise Flynn, Fernando Biase, Noam Meiri, Dongmin Liu, Paul Siegel, Mark Cline, Elizabeth Gilbert   +8 more
doaj   +2 more sources

Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. More than 30% of patients develop lung metastasis, which is the leading cause of mortality. Recently, the extracellular matrix protein Cyr61 has been recognized as a malignancy promoting protein in OS mouse model with prognostic potential in human OS.
Adam A. Sabile, Matthias Arlt, Roman Muff, Knut Husmann, Daniel Heß, Josefine Bertz, Bettina Langsam, Caroline Aemisegger, Urs Ziegler, Walter Born, Bruno Fuchs   +10 more
openalex   +3 more sources

Phase I First-in-Human Study of TRK-950, an IgG1 Antibody Specific to CAPRIN-1, in Patients with Advanced Solid Tumors. [PDF]

Cancer Res Commun
Cassier PA, Borad MJ, Sharma S, Dubois B, Caux C, Okano F, Von Hoff DD, Blay JY.   +7 more
europepmc   +3 more sources

Correction: Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget. [PDF]

Oncotarget, 2019
Qiu YQ, Yang CW, Lee YZ, Yang RB, Lee CH, Hsu HY, Chang CC, Lee SJ.   +7 more
europepmc   +2 more sources

Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage.

J Cell Sci, 2011
Towers ER, Kelly JJ, Sud R, Gale JE, Dawson SJ.   +4 more
europepmc   +3 more sources

Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer

Biology, 2022
In 1993, the discovery of microRNAs in Caenorhabditis elegans (C. elegans) altered the paradigmatic view of RNA biology and post-transcriptional gene regulation. Further study revealed the role of microRNAs in disease development and progression.
Faisal Aziz, Abhijit Chakraborty, Imran Khan, Josh Monts   +3 more
doaj   +1 more source