Results 31 to 40 of about 938 (119)

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget. [PDF]

Oncotarget, 2015
Qiu YQ, Yang CW, Lee YZ, Yang RB, Lee CH, Hsu HY, Chang CC, Lee SJ.   +7 more
europepmc   +3 more sources

circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR. [PDF]

Oncogene, 2023
AbstractCircular RNA (circRNA) is a novel RNA molecule characterized by covalently closed loop structure. Since its discovery, researchers have shown that circRNA is not “splicing noise” but a participant of various pathophysiological processes through unique mechanisms.
Liu J, Niu L, Hao J, Yao Y, Yan M, Li H.
europepmc   +3 more sources

Figure S4 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950

, 2023
<p>CAPRIN-1 expression following EMT induction.</p>
Fumiyoshi Okano, Takanori Saito, Yoshitaka Minamida, Shinichi Kobayashi, Takayoshi Ido, Yasushi Miyauchi, Ukei Wasai, Daisuke Akazawa, Masahiko Kume, Masaki Ishibashi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tetsu Yonehara   +13 more
openalex   +2 more sources

Caprin‐1 Promotes Cellular Uptake of Nucleic Acids with Backbone and Sequence Discrimination [PDF]

Helvetica Chimica Acta, 2019
AbstractThe cellular delivery of oligonucleotides has been a major obstacle in the development of therapeutic antisense agents. PNAs (Peptide Nucleic Acid) are unique in providing a modular peptidic backbone that is amenable to structural and charge modulation.
Valentina Galli, Kalyan K. Sadhu, Daniela Masi, Jacques Saarbach, Aurélien Roux, Nicolas Winssinger   +5 more
openalex   +3 more sources

Figure S9 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]

, 2023
<p>ADCC and ADCP activity of TRK-950 via human and monkey immune cells</p>
Fumiyoshi Okano, Takanori Saito, Yoshitaka Minamida, Shinichi Kobayashi, Takayoshi Ido, Yasushi Miyauchi, Ukei Wasai, Daisuke Akazawa, Masahiko Kume, Masaki Ishibashi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tetsu Yonehara   +13 more
openalex   +2 more sources

Figure S2 from Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950

, 2023
<p>CAPRIN-1 correlated to the cell proliferation and viability.</p>
Fumiyoshi Okano, Takanori Saito, Yoshitaka Minamida, Shinichi Kobayashi, Takayoshi Ido, Yasushi Miyauchi, Ukei Wasai, Daisuke Akazawa, Masahiko Kume, Masaki Ishibashi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tetsu Yonehara   +13 more
openalex   +2 more sources

Absence of Caprin-1 Results in Defects in Cellular Proliferation [PDF]

The Journal of Immunology, 2005
Abstract Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is a cytoplasmic phosphoprotein that is the prototype of a novel family of highly conserved proteins. Its levels, except in the brain, are tightly correlated with cellular proliferation.
Bin, Wang, Muriel D, David, John W, Schrader   +2 more
openaire   +2 more sources

Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer

Biology, 2022
In 1993, the discovery of microRNAs in Caenorhabditis elegans (C. elegans) altered the paradigmatic view of RNA biology and post-transcriptional gene regulation. Further study revealed the role of microRNAs in disease development and progression.
Faisal Aziz, Abhijit Chakraborty, Imran Khan, Josh Monts   +3 more
doaj   +1 more source

Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. More than 30% of patients develop lung metastasis, which is the leading cause of mortality. Recently, the extracellular matrix protein Cyr61 has been recognized as a malignancy promoting protein in OS mouse model with prognostic potential in human OS.
Adam A. Sabile, Matthias Arlt, Roman Muff, Knut Husmann, Daniel Heß, Josefine Bertz, Bettina Langsam, Caroline Aemisegger, Urs Ziegler, Walter Born, Bruno Fuchs   +10 more
openalex   +3 more sources

Two new miR‐16 targets: caprin‐1 and HMGA1, proteins implicated in cell proliferation [PDF]

Biology of the Cell, 2009
Background information. miRNAs (microRNAs) are a class of non‐coding RNAs that inhibit gene expression by binding to recognition elements, mainly in the 3′ UTR (untranslated region) of mRNA. A single miRNA can target several hundred mRNAs, leading to a complex metabolic network.
Rouault, Jean-Pierre, Kaddar, Tagrid, Chien, Wei Wen, Chebel, Amel, Gadoux, Mylène, Salles, Gilles, Ffrench, Martine, Magaud, Jean-Pierre   +7 more
openaire   +4 more sources