Results 41 to 50 of about 925 (119)
Cellular senescence: A potential mode of circular RNAs regulating prostate cancer
MedComm – Oncology, Volume 2, Issue 4, December 2023., 2023 Cellular senescence (CS) and circular RNAs (circRNAs) have been shown to have important roles in prostate cancer (PCa) tumorigenesis and progression. circRNAs can exert diverse functions in regulating CS through various pathways. CS affects PCa mainly via senescence‐associated secretory phenotype (SASP) while treatment against PCa induces cellular ...
Yunpeng Li +7 more
wiley +1 more source
The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster. [PDF]
PLoS Genetics, 2013 Appropriate expression of growth-regulatory genes is essential to ensure normal animal development and to prevent diseases like cancer. Gene regulation at the levels of transcription and translational initiation mediated by the Hippo and Insulin ...
Roland Baumgartner +2 more
doaj +1 more source
Regulation of ribonucleoprotein condensates by RNase L during viral infection
WIREs RNA, Volume 14, Issue 4, July/August 2023., 2023 RNase L‐mediated mRNA decay inhibits stress granule assembly and promotes the assembly of RNase L‐dependent bodies. Abstract In response to viral infection, mammalian cells activate several innate immune pathways to antagonize viral gene expression. Upon recognition of viral double‐stranded RNA, protein kinase R (PKR) phosphorylates the alpha subunit ...
James M. Burke
wiley +1 more source
Two new miR‐16 targets: caprin‐1 and HMGA1, proteins implicated in cell proliferation [PDF]
Biology of the Cell, 2009 Background information. miRNAs (microRNAs) are a class of non‐coding RNAs that inhibit gene expression by binding to recognition elements, mainly in the 3′ UTR (untranslated region) of mRNA. A single miRNA can target several hundred mRNAs, leading to a complex metabolic network.
Rouault, Jean-Pierre +7 more
openaire +4 more sources
Proteomic analysis of proton beam irradiated human melanoma cells. [PDF]
PLoS ONE, 2014 Proton beam irradiation is a form of advanced radiotherapy providing superior distributions of a low LET radiation dose relative to that of photon therapy for the treatment of cancer.
Sylwia Kedracka-Krok +8 more
doaj +1 more source
A little less aggregation a little more replication: Viral manipulation of stress granules
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley +1 more source
Cartographie fine de la région du gène PIS de la chèvre
INRAE Productions Animales, 2020 Chez les Mammifères, la différenciation sexuelle résulte d’une cascade complexe dont le premier acteur est le gène SRY, porté par le chromosome Y, qui masculinise la gonade indifférenciée.
E.P. CRIBIU, L. SCHIBLER, D. VAIMAN
doaj +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988 Les infections des ruminants sauvages par les herpèsvirus sont passées en revue : les infections par le virus de la thélite herpétique bovine, les formes européenne et africaine du coryza gangréneux et les infections par le virus de la maladie d ...
C. Meersschaert +2 more
doaj +1 more source
Chemoimmunotherapy in Advanced, PD-1 Refractory Cutaneous Squamous Cell Carcinoma: Insights From Two Immunocompromised Patient Cases. [PDF]
Case Rep Oncol MedCutaneous squamous cell carcinoma (cSCC) is one of the most prevalent malignancies worldwide, and a subset of patients, particularly immunocompromised individuals, will face heightened risks of metastasis and mortality. This report examines two cases of immunocompromised patients treated with a combination of platinum‐ and taxane‐based chemotherapy ...
Rahimi G, In GK.
europepmc +2 more sources
Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH [PDF]
, 2021 AbstractG3BP is the central hub within the protein-RNA interaction network of stress-induced bio-molecular condensates known as stress granules (SG). The SG-associated proteins Caprin-1 and USP10 exhibit mutually exclusive binding to the structured NTF2-domain of G3BP1, thereby regulating G3BP1-mediated condensation, but with opposite effects: Caprin-1
Tim Schulte +14 more
openaire +1 more source