Results 61 to 70 of about 2,300 (211)
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
Une enquête épidémiologique croisée a été effectuée sur des populations animales ciblées, en novembre 1988, dans le Sud de la Mauritanie, pour étudier l'incidence de la fièvre de la vallée du Rift.
Renaud Lancelot +5 more
doaj +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
Tiques et hémoparasitoses du bétail au Sénégal. IV. La zone Sud-soudanienne
Les auteurs rapportent les résultats d'une étude sur les tiques et les hémoparasitoses des bovins, des ovins et des caprins de la zone sud-soudanienne. Un détiquage systématique de 40 bovins, 40 ovins et 40 caprins est effectué pendant 15 mois, dans le ...
A. Gueye, M. Mbengue, A. Diouf
doaj +1 more source
Pastoral production and use of forest rangelands in Western Rif
Extensive livestock farming plays an important socio-economic role for goat farmers in Western Rif. Silvopastoral resources are the main source of feed for herds. Actually, these resources have a strong tendency to degradation.
Y. Chebli +4 more
doaj +1 more source
Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur +4 more
wiley +1 more source
(A) Caprin-1 or Caprin-2 was overexpressed in HEK-293 cells with LEF-1 and LEF-luciferase reporter
14 h after transfection, cells were treated with control or Wnt-3a conditioned medium (CM) for 6 h, then luciferase activity was determined (top). To detect the β-catenin level in cytosol, cells were stimulated with Wnt-3a CM for 3 h and examined by anti–
Ting Chen (15205) +9 more
core +1 more source
RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration
Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins +5 more
wiley +1 more source
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu +17 more
wiley +1 more source
La gestion de la saisonnalité de la production laitière est une difficulté pour les entreprises de collecte et de transformation. Nous avons exploré ici l’intérêt de valoriser des complémentarités entre des systèmes de production présents sur un bassin ...
Martine Napoléone
doaj +1 more source

