Results 61 to 70 of about 2,792 (204)
Advanced Science, Volume 13, Issue 6, 30 January 2026.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, Volume 9, Issue 12, December 2025.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
(A) Caprin-1 or Caprin-2 was overexpressed in HEK-293 cells with LEF-1 and LEF-luciferase reporter
, 2011 14 h after transfection, cells were treated with control or Wnt-3a conditioned medium (CM) for 6 h, then luciferase activity was determined (top). To detect the β-catenin level in cytosol, cells were stimulated with Wnt-3a CM for 3 h and examined by anti–
Ting Chen (15205) +9 more
core +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2019 La gestion de la saisonnalité de la production laitière est une difficulté pour les entreprises de collecte et de transformation. Nous avons exploré ici l’intérêt de valoriser des complémentarités entre des systèmes de production présents sur un bassin ...
Martine Napoléone
doaj +1 more source
Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
FASEB BioAdvances, Volume 7, Issue 11, November 2025.Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur +4 more
wiley +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988 La trop fréquente absence de gestion des parcours naturels sahéliens est unanimement dénoncée. Malheureusement, outre les difficultés rencontrées pour mettre en œuvre les mesures les plus urgentes telles que la mise en défens des parcours, la réduction ...
Hubert Guérin
doaj +1 more source
RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins +5 more
wiley +1 more source
Note sur deux foyers d’ecthyma contagieux du mouton et de la chèvre au Sénégal
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988 Au Sénégal, dans les conditions naturelles, le virus de l’ecthyma contagieux du mouton et de la chèvre peut se maintenir dans les troupeaux infectés pendant de très longues périodes.
J. Sarr, M. Diop, S. Cissokho
doaj +1 more source
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
Advanced Science, Volume 12, Issue 34, September 11, 2025.These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu +17 more
wiley +1 more source
Lev Vygotskij, figura e opera da (ri)scoprire. Un contributo alle teorie dell’educazione [PDF]
, 2015 Dopo un’introduzione alla figura e al pensiero di Lev Vygotskij, se ne esaminano gli aspetti relativi alle influenze storico-culturali sulle modalità di funzionamento cognitivo umano, con attinenza alla psicologia dello sviluppo e dell’educazione ...
Zudini V +3 more
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