Results 11 to 20 of about 1,537 (165)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Minimalist, bioinspired and sensorial emulsion based on a Ca2+ double cone vector system using Design of Experiment (DoE)

International Journal of Cosmetic Science, EarlyView.
Development of a biomimetic calcium‐based minimalist skin formulation using Design of Experiment (DoE) to correlate key ingredients' effect on the sensory and physico‐chemical properties of the emulsion. Abstract Objectives Innovation is considered a determining factor in the highly competitive environment of the cosmetic industry to introduce products
Marc Lavarde, Marjorie Lassalle, Solène Gouot, Ysaline Corroyer, Clara Marceau, Vincent Briffaut, Stéphane Poigny, Samar Issa   +7 more
wiley   +1 more source

Exploring the microbiota–skin–brain axis: Chicory extract biotransformed into a postbiotic neurocosmetic enhancer of social and sensory experience

International Journal of Cosmetic Science, EarlyView.
Application of CHICORY EXTRACT by a consumer has the ability to evoke positive emotional responses in individuals who come into tactile contact with the treated skin. Abstract Objective Measuring the influence of cosmetic ingredients on the microbiota‐skin‐brain axis is a difficult challenge.
Stefan Hettwer, Emina Besic Gyenge, Loya Schoeffel, Brigit Suter, Barbara Obermayer   +4 more
wiley   +1 more source

Ozonized Hydrogel and Chlorhexidine Gel for Peri‐Implant Mucositis: A 24‐Month Randomized Controlled Trial

Oral Diseases, EarlyView.
ABSTRACT Objective This randomized controlled trial evaluated the 24‐month effectiveness of a nonsurgical intervention for peri‐implant mucositis, comparing a 15% ozonated sunflower oil hydrogel with a 1% chlorhexidine gel. Methods Thirty patients with 360 peri‐implant mucositis sites were treated in a split‐mouth design, receiving both therapies in ...
Andrea Scribante, Maurizio Pascadopoli, Matteo Pellegrini, Marco Saturnino Lupi, Carlos Pérez‐Albacete Martínez, Andrea Butera   +5 more
wiley   +1 more source

Engineering Marker‐Free Lettuce Chloroplast Genome to Express Functional Glucagon‐Like Peptide‐1 Receptor Agonists Exenatide and Lixisenatide

Plant Biotechnology Journal, EarlyView.
Engineering of marker‐free lettuce chloroplast genome to express CTB‐Exenatide and CTB‐Lixisenatide for oral delivery. Upper panel: Chemically synthesised exenatide or lixisenatide require expensive production, purification, refrigeration and invasive delivery methods.
Rahul Singh, Henry Daniell
wiley   +1 more source

A signaling pathway mediating abscisic acid‐induced jasmonic acid biosynthesis during strawberry ripening

Journal of Integrative Plant Biology, Volume 68, Issue 3, Page 777-792, March 2026.
During strawberry ripening, abscisic acid signaling activates SnRK2.6, which phosphorylates and degrades the JAZ12 repressor. This releases the MYC2 transcription factor, directly activating jasmonic acid biosynthesis genes. The resulting jasmonic acid accumulation drives aroma production, thereby coupling ripening with scent formation through this ...
Kenan Jia, Baozhen Zeng, Zhengrong Dai, Xiaoming Zhang, Jing Wang, Chuanbao Wu, Chen Feng, Guohua Yan, Kaichun Zhang, Xuwei Duan, Wei Wang   +10 more
wiley   +1 more source

Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
Chewable softgels are a patient‐preferred alternative to conventional oral forms, offering pleasant taste, fast onset, and suitability for children or patients with swallowing difficulties. However, they present relevant challenges in their formulation: the shell must balance chewability, machinability, and stability, while the fill must mask the ...
Almudena Naharros‐Molinero, María Ángela Caballo‐González, Francisco Javier de la Mata, Sandra García‐Gallego   +3 more
wiley   +1 more source

Conjugative Transfer of Disease‐Encoding Plasmid Variants in Serratia spp. Alter Production of Enzymes and Virulence Properties

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Analysis of plasmid transconjugants relative to plasmid‐free and plasmid‐carrying Serratia spp. demonstrates erratic disease phenotypes and reduced fitness. Transconjugants also show reduced ability to degrade substrates associated with virulence, supported by transcriptomic data.
Amy L. Vaughan, Travis R. Glare, Charles A. Hefer, Mark R. H. Hurst   +3 more
wiley   +1 more source

Correspondence to ‘Hypersensitivity Reactions to Human Albumin—A Case Series and Diagnostic Algorithm’

Allergy, EarlyView.
Juliette Charpy, Mathilde Seydoux, Antoine Giraudon, Julien Bonnac, Maxime Dubois, Maryline Bordes‐Demolis, Christelle Pellerin, Julien Goret   +7 more
wiley   +1 more source

Cosmeceutical and Dermatological Potential of Shiitake Mushroom (Lentinula edodes) Extract

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Shiitake mushroom (Lentinula edodes) contains polysaccharides, phenolics, and β‐glucans known for their antioxidant and nutraceutical properties; however, its dermatological applications remain limited. Objective This study aimed to evaluate the antioxidant potential, enzyme inhibition activities, and cytotoxicity of freeze‐dried ...
Sibel Dikmen Kucuk, Paul Jabet, Anthony Groso, Guillaume Collet, Richard Daniellou, Beste Karadeniz   +5 more
wiley   +1 more source