Results 151 to 160 of about 71,965 (172)
Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process
Biotechnology and Bioengineering, Volume 122, Issue 6, Page 1424-1440, June 2025.ABSTRACT Increasing demand for recombinant adeno‐associated virus (rAAV)‐based gene therapies necessitates increased manufacturing production. Transient transfection of mammalian cells remains the most commonly used method to produce clinical‐grade rAAVs due to its ease of implementation.
Tam N. T. Nguyen +11 more
wiley +1 more source
Human Herpesvirus‐6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult
Brain and Behavior, Volume 15, Issue 6, June 2025.Human Herpesvirus‐6 infectious meningitis with lymphadenitis in an immunocompetent adult. CSF: cerebrospinal fluid; NGS: next‐generation sequencing; HHV‐6: Human herpes virus‐6 ABSTRACT Purpose Human Herpesvirus 6 (HHV‐6) infections are primarily observed in immunocompromised individuals, such as those with acquired immunodeficiency syndrome or organ ...
Yu Xie +9 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 1872-1882, June 2025.Abstract Aims miRNAs, small non‐coding RNAs, play key roles in gene regulation, cell differentiation and tissue development. They influence viral infection outcomes by directly interacting with viral genomes or modifying the host microenvironment. This study demonstrates miRNAs' ability to selectively suppress transcriptionally active erythroparvovirus,
Ganna Aleshcheva +5 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.ABSTRACT Neuronal extracellular vesicles (microvesicles and exosomes) are emerging secreted vesicular signals that play important roles in the CNS. Currently, little is known about how glutamatergic signalling affects the subcellular localisation of exosome precursor intraluminal vesicles (ILVs), microRNA (miR) packaging into ILVs and in vivo spreading
Marcela Bertolio +9 more
wiley +1 more source
Faba Bean Breeding in Australia: Past, Present and Future
Legume Science, Volume 7, Issue 2, June 2025.ABSTRACT Faba bean is an important autumn‐sown grain legume in Australia, coming third in production and hectarage after lentil and chickpea. It is mostly grown in South Australia, Victoria, New South Wales (NSW) and Queensland (QLD). Despite its introduction as early as European settlement in Australia, the crop did not get much attention until the ...
Kedar N. Adhikari +2 more
wiley +1 more source
Microbial Ecology of Permafrost Soils: Populations, Processes, and Perspectives
Permafrost and Periglacial Processes, Volume 36, Issue 2, Page 245-258, April/June 2025.ABSTRACT Permafrost microbial research has flourished in the past decades, due in part to improvements in sampling and molecular techniques, but also the increased focus on the permafrost greenhouse gas feedback to climate change and other ecological processes in high latitude and alpine permafrost soils.
Mark P. Waldrop +33 more
wiley +1 more source
CXXC5 is a ubiquitinated protein and is degraded by the ubiquitin‐proteasome pathway
Protein Science, Volume 34, Issue 6, June 2025.Abstract CXXC5, as a member of the zinc‐finger CXXC family proteins, interacts with unmodified CpG dinucleotides to modulate the expression of genes involved in cellular proliferation, differentiation, and death in physiology and pathophysiology. Various signaling pathways, including mitogenic 17β‐estradiol (E2), contribute to the expression and ...
Hazal Ayten +10 more
wiley +1 more source
Design and evolution of a synthetic small protein scaffold based on the WW domain
Protein Science, Volume 34, Issue 6, June 2025.Abstract Protein engineering is a powerful tool in biotechnology and the basis to create unprecedented sequences, structures, and functions. The WW domains are a family of naturally occurring proteins involved in the molecular recognition of proline‐rich and phosphorylated peptide sequences with relevance in cellular processes involved in human ...
Ana Margarida Gonçalves Carvalho Dias +5 more
wiley +1 more source
AcrDB update: Predicted 3D structures of anti‐CRISPRs in human gut viromes
Protein Science, Volume 34, Issue 6, June 2025.Abstract Anti‐CRISPR (Acr) proteins play a key role in phage‐host interactions and hold great promise for advancing genome‐editing technologies. However, finding new Acrs has been challenging due to their low sequence similarity. Recent advances in protein structure prediction have opened new pathways for Acr discovery by using 3D structure similarity.
Minal Khatri +4 more
wiley +1 more source
Therapeutic options for human papillomavirus‐positive tonsil and base of tongue cancer
Journal of Internal Medicine, Volume 297, Issue 6, Page 608-629, June 2025.Abstract The incidences of human papillomavirus‐positive (HPV+) tonsillar and base tongue squamous cell carcinomas (TSCC and BOTSCC) have increased in recent decades. Notably, HPV+ TSCC and BOTSCC have a significantly better prognosis than their HPV‐negative counterparts when treated with current surgical options, radiotherapy, or intensified ...
Mark Zupancic +3 more
wiley +1 more source