Results 151 to 160 of about 174,454 (241)

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism. [PDF]

Nat Commun
Fokine A, Zhu J, Klose T, Vago F, Arnaud CA, Wang Z, Khare B, Rossmann MG, Chen Z, Sun L, Fang Q, Kuhn RJ, Rao VB.   +12 more
europepmc   +1 more source

Advances in endothelial cell targeting by AAV vectors. [PDF]

Acta Biochim Pol
Cichon M, Jozkowicz A, Grochot-Przeczek A.   +2 more
europepmc   +1 more source

Immune Response Associated Hepatotoxicity in Hemophilia Gene Therapy: Mechanisms, Management, and Challenges. [PDF]

J Hematol
Zheng CC.
europepmc   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses. [PDF]

Proc Natl Acad Sci U S A
Zhang X, Richart D, McFarlin S, Cheng F, Park SY, Zhang-Chen A, McFarlane R, Xiao C, Yan Z, Qiu J.   +9 more
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, Volume 13, Issue 14, 9 March 2026.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry. [PDF]

Microbiol Spectr
Zhang W, Liu Y, Li Q, Yi D, Liu Q, Guo S, Wang J, Zhao J, Ma L, Ding J, Zhou R, Ren Y, Talpbek Y, Li X, Zhang Y, Cen S.   +15 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, Volume 13, Issue 16, 18 March 2026.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source