Results 161 to 170 of about 71,965 (172)
Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light
Neurogastroenterology &Motility, Volume 37, Issue 6, June 2025.Optogenetic stimulation enables direct and selective stimulation of smooth muscle cells and thus provides a new opportunity to restore gastric contractility in cases of gastroparesis. Herein, we demonstrate that hOPN5 is a new and effective tool acting via Gq signaling and is thus complementary to light‐induced membrane depolarization with ...
David Zipf +6 more
wiley +1 more source
Cas9‐Rep fusion tethers donor DNA in vivo and boosts the efficiency of HDR‐mediated genome editing
Plant Biotechnology Journal, Volume 23, Issue 6, Page 2006-2017, June 2025.Summary Genome editing based on the homology‐directed repair (HDR) pathway enables scar‐free and precise genetic manipulations. However, the low frequency of HDR hinders its application in plant genome editing. In this study, we engineered the fusion of Cas9 and a viral replication protein (Rep) as a molecular bridge to tether donor DNA in vivo, which ...
Zhentao Zhou +7 more
wiley +1 more source
Plant Pathology, Volume 74, Issue 5, Page 1277-1289, June 2025.A shift in Begomovirus coheni populations associated with tomato yellow leaf curl disease (TYLCD) in tomato cultivars might facilitate the emergence of tomato yellow leaf curl virus‐Georgia (TYLCV‐GA) in natural conditions. ABSTRACT Tomato yellow leaf curl virus (TYLCV) is a major pathogen causing tomato yellow leaf curl disease (TYLCD), significantly ...
Manish Kumar +5 more
wiley +1 more source
Megalocytivirus: A Review of Epidemiology, Pathogenicity, Immune Evasion, and Prevention Strategies
Reviews in Aquaculture, Volume 17, Issue 3, June 2025.ABSTRACT Megalocytivirus, a large double‐stranded DNA virus belonging to the Iridoviridae family, has infected over 100 species of fish, leading to significant economic losses in the aquaculture, food, and ornamental fish industries. These viruses exhibit icosahedral symmetry and have diameters ranging from 120 to 200 nm.
Changjun Guo +4 more
wiley +1 more source
Scientific approaches to defining HPV vaccine‐induced protective immunity
International Journal of Cancer, Volume 156, Issue 10, Page 1848-1857, 15 May 2025.Abstract Seventeen years after the licensure of prophylactic human papillomavirus (HPV) L1 virus‐like‐particle vaccines, a defined antibody level that correlates with vaccine‐induced protection against HPV infections and associated neoplasia is missing.
Matti Lehtinen +6 more
wiley +1 more source
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2018
The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration.
Louis M. Mansky +2 more
openaire +3 more sources
The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration.
Louis M. Mansky +2 more
openaire +3 more sources
Current HIV Research, 2003
HIV Gag assembly is the first and most essential step in the formation of virus particles. Following protein synthesis, Gag relocates from ribosomes and forms a virus particle at the plasma membrane, using host factors and machinery. Early studies focused on mapping the regions within Gag required for assembly and identified three distinct domains (M ...
openaire +3 more sources
HIV Gag assembly is the first and most essential step in the formation of virus particles. Following protein synthesis, Gag relocates from ribosomes and forms a virus particle at the plasma membrane, using host factors and machinery. Early studies focused on mapping the regions within Gag required for assembly and identified three distinct domains (M ...
openaire +3 more sources
Formation of empty B19 parvovirus capsids by the truncated minor capsid protein
Journal of Virology, 1994We previously reported that empty capsids of B19 parvovirus were formed by the major capsid protein (VP2) alone expressed in a baculovirus system, but the minor capsid protein (VP1), longer by 227 amino acids, alone did not form empty capsids. We report here further investigations of the constraints on capsid formation by truncated versions of VP1 ...
Sachiko Kajigaya +4 more
openaire +3 more sources
2008
Coat proteins (CPs) of all plant viruses have an early function in disassembly of parental virus and a late function in assembly of progeny virus. Depending on the virus, however, CPs may play a role in many steps of the infection cycle in between these early and late functions.
openaire +3 more sources
Coat proteins (CPs) of all plant viruses have an early function in disassembly of parental virus and a late function in assembly of progeny virus. Depending on the virus, however, CPs may play a role in many steps of the infection cycle in between these early and late functions.
openaire +3 more sources
Modifying Filamentous Phage Capsid: Limits in the Size of the Major Capsid Protein
Journal of Molecular Biology, 1995Ff filamentous phages are long thin cylindrical structures that infect bacteria displaying the F pilus and replicate without lysing the host. These structures are exploited to display peptides by fusing them to the amino terminus of either the bacterial receptor protein (pIII) or the major coat protein (pVIII).
Gianni Cesareni +3 more
openaire +3 more sources