Results 61 to 70 of about 3,526,441 (295)

Enhancing Capsid Proteins Capacity in Plant Virus-Vector Interactions and Virus Transmission

Cells, 2021
Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for ...
Alexey Agranovsky
doaj   +1 more source

The structure of a plant-specific partitivirus capsid reveals a unique coat protein domain architecture with an intrinsically disordered protrusion [PDF]

, 2021
Persistent plant viruses may be the most common viruses in wild plants. A growing body of evidence for mutualism between such viruses and their hosts, suggests that they play an important role in ecology and agriculture.
Ranson, N, Byrne, M, Esquirol, L, Sainsbury, Frank, Kashyap, A, Esquirol, Lygie, Ranson, Neil, Byrne, Matthew, Sainsbury, F, Kashyap, Aseem   +9 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Identification of Plant Peptides as Novel Inhibitors of Orthohepevirus A (HEV) Capsid Protein by Virtual Screening

Molecules, 2023
Hepatitis E virus (HEV) is the notable causative agent of acute and chronic hepatic, renal, pancreatic, neurological, and hematopoietic blood cell infections with high risk in immunocompromised patients. Hepatic failure is mostly documented among adults,
Ghulam Mustafa, Hafiza Salaha Mahrosh, Syed Awais Attique, Rawaba Arif, Mohammad Abul Farah, Khalid Mashay Al-Anazi, Sajad Ali   +6 more
doaj   +1 more source

Assembly of the Hv190S Totivirus Capsid Is Independent of Posttranslational Modification of the Capsid Protein

Virology, 1998
The genome of Helminthosporium victoriae 190S totivirus (Hv190SV) consists of two large overlapping open reading frames (ORFs), encoding a capsid protein (CP) and an RNA-dependent RNA polymerase. The capsid of Hv190SV, even though encoded by a single gene, contains three closely related capsid polypeptides: p88, p83, and p78.
Soldevila, Ana I., Huang, Shao, Ghabrial, Said A.   +2 more
openaire   +2 more sources

FMDV replicons encoding green fluorescent protein are replication competent [PDF]

, 2014
The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by
Stonehouse, Nicola J., Tulloch, Fiona Ashley, Ryan, MD, Rowlands, DJ, Jackson, T, Pathania, Uday, Ryan, Martin D, Tuthill, Toby, Lamond, Angus I.; id_orcid, Rowlands, David J, Nicholson, J, Rowlands, David J., Tulloch, F, Luke, GA, Luke, Garry A., Nicholson, John, Lamond, Angus I., Luke, Garry A, Lamond, Angus I, Haas, Juergen, Ryan, Martin D., Tuthill, T, Hass, Juergen, Tulloch, Fiona, Luke, Garry Alec, Stonehouse, Nicola J, Jackson, Terry, Lamond, AI, Ryan, Martin Denis, Pathania, U, Haas, J, Pathania, Uday Singh, Stonehouse, NJ   +32 more
core   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

hepatitis c Virus p7 is critical for capsid assembly and envelopment.

PLoS Pathogens, 2013
Hepatitis C virus (HCV) p7 is a membrane-associated ion channel protein crucial for virus production. To analyze how p7 contributes to this process, we dissected HCV morphogenesis into sub-steps including recruitment of HCV core to lipid droplets (LD ...
Juliane Gentzsch, Christiane Brohm, Eike Steinmann, Martina Friesland, Nicolas Menzel, Gabrielle Vieyres, Paula Monteiro Perin, Anne Frentzen, Lars Kaderali, Thomas Pietschmann   +9 more
doaj   +1 more source

Structural roles of PCV2 capsid protein N-terminus in PCV2 particle assembly and identification of PCV2 type-specific neutralizing epitope. [PDF]

PLoS Pathogens, 2019
Postweaning multisystemic wasting disease (PMWS) in piglets caused by porcine circovirus type 2 (PCV2) is one of the major threats to most pig farms worldwide.
Xiaobing Mo, Xiangdong Li, Bo Yin, Junhua Deng, Kegong Tian, Adam Yuan   +5 more
doaj   +1 more source