Results 61 to 70 of about 134,019 (273)

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

A Porphyromonas gingivalis Capsule-Conjugate Vaccine Protects From Experimental Oral Bone Loss

Frontiers in Oral Health, 2021
Periodontal diseases are chronic inflammatory diseases of the periodontium that result in progressive destruction of the soft and hard tissues supporting the teeth, and it is the most common cause of tooth loss among adults.
Fernanda G. Rocha, Aym Berges, Angie Sedra, Shirin Ghods, Neeraj Kapoor, Lucy Pill, Mary Ellen Davey, Jeff Fairman, Frank C. Gibson   +8 more
doaj   +1 more source

Chemical shift assignments of the type d capsular polysaccharide purified from BB270.

, 2016
Chemical shift assignments of the type d capsular polysaccharide purified from BB270.
Kimberly F. Starr (464984), Pablo Yagupsky (160677), L. Scott Forsberg (3227367), Eric A. Porsch (464985), Radnaa Naran (3227364), Uri Amit (3227370), Patrick C. Seed (192918), Christian Heiss (446842), Parastoo Azadi (223686), Joseph W. St. Geme III (248201)   +9 more
core   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Development and evaluation of a novel vaccine against prevalent invasive multi-drug resistant strains of Streptococcus pneumoniae [PDF]

PeerJ, 2016
Streptococcus pneumoniae is a pathogen that causes serious invasive infections, such as septicemia, meningitis and pneumonia in addition to mild upper respiratory tract infections. Protection from pneumococcal diseases is thought to be mediated mainly by
Rehab H. Bahy, Hayam M. Hamouda, Amal S. Shahat, Aymen S. Yassin, Magdy A. Amin   +4 more
doaj   +2 more sources

The Structure of Aerobacter aerogenes Capsular Polysaccharide

Journal of Biological Chemistry, 1971
A capsular polysaccharide produced by Aerobacter aerogenes has been purified and shown to consist of galactose, mannose, and glucuronic acid in a molar ratio of 2:1:1, respectively. Partial acid hydrolysis liberated an aldobiouronic acid identified as 2-O-β- d -glucuronosyl- d -mannose. Analysis of capsular polysaccharide by Smith periodate degradation
E C, Yurewicz, M A, Ghalambor, E C, Heath   +2 more
openaire   +2 more sources

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

Streptococcus pneumoniae serotype 33H: a novel serotype with frameshift mutations in the acetyltransferase gene wciG

Pneumonia
Background Streptococcus pneumoniae (the pneumococcus) is a leading cause of community-acquired pneumonia. Pneumococci are categorised into serotypes, based on the type of capsular polysaccharide produced, which has important implications for virulence ...
Sam Manna, Belinda D. Ortika, Joel P. Werren, Casey L. Pell, Ilche Gjuroski, Stephanie W. Lo, Jason Hinds, Odgerel Tundev, Eileen M. Dunne, Bradford D. Gessner, Fiona M. Russell, E. Kim Mulholland, Tuya Mungun, Claire von Mollendorf, Stephen D. Bentley, Markus Hilty, Neil Ravenscroft, Catherine Satzke   +17 more
doaj   +1 more source

Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form

Frontiers in Pharmacology, 2020
The prominent human symbiont Bacteroides fragilis protects animals from intestinal diseases, such as ulcerative colitis, and its capsular polysaccharide plays a key role in reducing inflammation. B. fragilis strain ZY-312 was isolated from the feces of a
Lijun Zheng, Lijun Zheng, Meihua Luo, Gaobo Kuang, Yangyang Liu, Debao Liang, Haiqing Huang, Xiaomin Yi, Congfeng Wang, Ye Wang, Qiuling Xie, Fachao Zhi   +11 more
doaj   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source