Results 61 to 70 of about 47,119 (210)

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues [PDF]

, 2011
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress.
Doctrow, Susan R., Fish, Brian, Hill, Richard P., Huffman, Karl D., Lazarova, Zelmira, Mahmood, Javed, Medhora, Meetha, Molthen, Robert C., Moulder, John E., Rosenthal, Rosalind A., Sonis, Stephen T., Tofilon, Philip J.   +11 more
core   +2 more sources

Multi‐Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre‐Frail Older Men by Losartan

Aging Cell, Volume 25, Issue 5, May 2026.
Losartan partially reversed serum metabolomic aging signatures in both aged mice and pre‐frail older men, and this effect required functional angiotensin II receptors in mice. Cross‐species analyses suggest aging shifts circulating metabolites in opposite directions in mice versus humans, particularly among lipids, with losartan partially normalizing ...
Michael R. Bene, Cissy Zhang, Reyhan Westbrook, Mariann Gabrawy, Ruth Marx, Yuqiong Wu, Mohammed Khadeer, Ceereena Ubaida‐Mohien, Luigi Ferrucci, Ruin Moaddel, Anne Le, Jeremy D. Walston, Jessica L. Lee, Peter M. Abadir   +13 more
wiley   +1 more source

The stability of an Captopril oral solution prepared from tablets

Journal of Health Science and Medical Research (JHSMR), 2006
Objective: To develop extemporaneous captopril oral solution 1 mg/ml for use in child patients at Songklanagarind Hospital. The formulation was prepared from commercially available 25 mg captopril tablet.
P Supattanakul, P Apiromrak, C Ovatlarnporn   +2 more
doaj  

Practical Spectrophotometric Assay for the \u3cem\u3edapE\u3c/em\u3e-Encoded \u3cem\u3eN\u3c/em\u3e-Succinyl-L,L-Diaminopimelic Acid Desuccinylase, a Potential Antibiotic Target [PDF]

, 2018
A new enzymatic assay for the bacterial enzyme succinyl-diaminopimelate desuccinylase (DapE, E.C. 3.5.1.18) is described. This assay employs N6-methyl-N2-succinyl-L,L-diaminopimelic acid (N6-methyl-L,L-SDAP) as the substrate with ninhydrin used to detect
Ballicora, Miguel A., Becker, Daniel P., Guzman, Estefany R., Heath, Tahirah K., Herbert, Claire A., Holz, Richard C., Lutz, Marlon R., Jr., Nocek, Boguslaw P., Olsen, Kenneth W., Reidl, Cory   +9 more
core   +1 more source

Emerging Techniques for the Extraction and Enzymatic Hydrolysis of Plant Proteins From Waste: An Integrative Review

Journal of Food Process Engineering, Volume 49, Issue 5, May 2026.
The graphical abstract presents plant protein sources and emerging extraction and enzymatic hydrolysis techniques, highlighting innovative technologies to increase yield, preserve nutritional quality, and generate hydrolysates and bioactive peptides with potential health benefits and sustainable industrial applications. ABSTRACT The growth of the world
Lara Louzada Aguiar, Roberta Soares Cabral, Vinícius Serafim Coelho, Bruna Vieira Nunes, Viviane Dias Medeiros Silva, Gabriel Barbosa de Oliveira, Renata Adriana Labanca, Julio Onesio‐Ferreira Melo, Raquel Linhares Bello de Araújo   +8 more
wiley   +1 more source

Consumption Time of Captopril Influenced the Outcomes of Patients with Stage 1 Hypertension

Pharmacology and Clinical Pharmacy Research, 2017
Differences in drugs consumption time may affect its absorption and metabolism in the body which could lead to differences in its efficacy. For hypertension patients, one of the most frequently used drugs for lowering blood is captopril.
Sulastri Herdaningsih, Ahmad Muhtadi, Keri Lestari   +2 more
doaj   +1 more source

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography

Scientific Reports, 2021
Angiotensin converting enzyme inhibitors, among them captopril, improve survival following myocardial infarction (MI). The mechanisms of captopril action remain inadequately understood due to its diverse effects on multiple signalling pathways at ...
Urmas Roostalu, Louise Thisted, Jacob Lercke Skytte, Casper Gravesen Salinas, Philip Juhl Pedersen, Jacob Hecksher-Sørensen, Bidda Rolin, Henrik H. Hansen, James G. MacKrell, Robert M. Christie, Niels Vrang, Jacob Jelsing, Nora Elisabeth Zois   +12 more
doaj   +1 more source

Effect of short time captopril administration on spatial memory in aging rats [PDF]

, 2015
Introduction: The brain renin-angiotensin system (RAS) has been reported having a pathological role in age-related impairment in learning and memory. Therefore, angiotensin converting enzyme inhibitors (ACEi) are expected to have positive ef fects on ...
Bakhshandeh, F., Ganji, F., Sepehri, H.
core  

Hypertensive Urgency and Pulmonary Infiltrates: A Report of Three Cases

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Hypertensive urgency is commonly attributed to medication nonadherence, progression of essential hypertension, or secondary causes. However, in some patients, no clear precipitating factor is identified, despite repeated evaluations and the absence of target organ damage. Subclinical inflammatory conditions have been hypothesized as potential,
Mónica Contreras‐Moreira
wiley   +1 more source