Results 111 to 120 of about 5,341,225 (274)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
LE CAPTAGE DU CO2 DANS LES CENTRALES THERMIQUES
Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2010 This review is devoted to assess and compare various processes aiming at recover CO2 from power plants fed with natural gas (NGCC) and pulverized coal (PC).
Chakib Bouallou
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Capture and Protection of Environmental DNA in a Metal‐Organic Framework
Small ScienceEnvironmental DNA (eDNA) is released by organisms into their surroundings, enabling non‐invasive species detection and biodiversity assessments without the need for direct observation.
Laura I. FitzGerald +5 more
doaj +1 more source
AnimalsWhen standard methods of human–elephant conflict mitigation are not successful, free-ranging wild elephants may continue to come into close contact with people.
Khyne U. Mar
doaj +1 more source
Culture Unbound: Journal of Current Cultural Research, 2014 For many years, the concept of cognitive capitalism has been an important subject for elaboration, discussions, and polemics. In this essay, we will not summarize the various theoretical details of the debate; instead, we will try to clarify the ...
Gigi Roggero
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source