Results 111 to 120 of about 2,265,093 (319)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A spatially explicit capture-recapture estimator for single-catch traps
, 2015 This work was part-funded by EPSRC grant EP/I000917/1.1. Single-catch traps are frequently used in live-trapping studies of small mammals. Thus far a likelihood for single-catch traps has proven elusive and usually the likelihood for multi-catch traps is
Distiller, Greg +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Financing urban transport through value capture.
, 2010 The Green Paper on Urban Transport highlights the importance of promoting public transport as a means of achieving better sustainable mobility. Unfortunately, budget resources are often constrained. On the other hand, literature points out that transport
Mejía Dorantes, Lucía +1 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Efficient and rapid screening of novel adsorbents for carbon capture in the UK IGSCC project
, 2013 Here we present the results of the rapid screening of novel adsorbents for CO capture. The materials were synthesized as part of the Innovative Gas Separations for Carbon Capture (IGSCC) project, a UK wide consortium which involves the University of ...
Lozinska, M.L. +20 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Letter to Editor Regarding the OCEAN Study [Letter]
International Journal of COPD, 2021 Barbara P Yawn,1 Barry Make,2 David Mannino,3 Fernando J Martinez,4 Meilan K Han5 1Department of Family and Community Health, University of Minnesota, Minneapolis, MN, USA; 2Pulmonary Sciences and Critical Care Medicine, National Jewish Health, Denver ...
Yawn BP +4 more
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