Results 241 to 250 of about 2,712,717 (312)

Advancing adoptive T cell therapy in ovarian cancer: barriers, innovations, and emerging platforms. [PDF]

J Immunother Cancer
Santos GNS, DeJohn C, Hess SM, Zsiros E, McGray AJR.   +4 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Combining Microwave Ablation With CAR-T-Cell Therapy in Tumor-Bearing Mouse Models. [PDF]

Bio Protoc
Cao B, Wheeler GL, Mast J, Zhao Q, Shen J.   +4 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Qwen TextCNN and BERT models for enhanced multilabel news classification in mobile apps. [PDF]

Sci Rep
Yuan D, Liang G, Liu B, Liu S.
europepmc   +1 more source

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signaling. [PDF]

Cell Commun Signal
Sun S, Zhao W, Liang Y, Xue Y, Li Q, Yuan Y, Wang Z, Gao X, Yao Y, Xu H, Li H, Liu X, Tang PM, Zheng J, Zhang Q.   +14 more
europepmc   +1 more source

Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy. [PDF]

Nat Commun
Gu K, Liang T, Hu L, Zhao Y, Ying W, Zhang M, Chen Y, Liang B, Lin X, Zhang Y, Wu H, Wang M, Zhu Y, Wang W, Zhang Y, Zuo C, Du Z, Zhang P, Song J, Li L, Liu X, Xie S, Tan W.   +22 more
europepmc   +1 more source

Next-generation CAR-T therapy for acute myeloid leukemia: bridging innovation with clinical translation. [PDF]

Ann Hematol
Zhao X, Ming X, Wu J, Zhu X, Xiao Y.
europepmc   +1 more source