Results 11 to 20 of about 293,272 (302)
Immunological Medicine, 2021 Chimeric antigen receptor (CAR) is generated by fusing a cancer-specific antibody’s antigen recognition site with costimulatory molecules such as CD28 and CD3ζ. T cells transduced with CAR recognizes cancer-specific antigens and kill cancer cells.
Naoki Hosen
doaj +5 more sources
CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
Frontiers in Immunology, 2023 Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory ...
Simone Thomas +3 more
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Preventing trogocytosis by cathepsin B inhibition augments CAR T-cell function [PDF]
Signal Transduction and Targeted TherapyChimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in cancer treatment. Nevertheless, most patients receiving CAR T cells relapse within 5 years of treatment. CAR-mediated trogocytosis (CMT) is a potential tumor escape mechanism
Kenneth A. Dietze +18 more
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Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions
Cells, 2023 T cells expressing chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for TCR-mediated T cell activation ...
Julia Sajman +7 more
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Biomedicines, 2022 High-grade serous ovarian carcinoma (HGSOC) is the most common type of epithelial ovarian cancer. The majority of cases are diagnosed at advanced stages, when intraperitoneal (IP) spread has already occurred.
Naamit Deshet-Unger +17 more
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Frontiers in Medicine, 2023 BackgroundManually keeping up-to-date with regulations such as directives, guidance, laws, and ordinances related to cell and gene therapy is a labor-intensive process. We used machine learning (ML) algorithms to create an augmented intelligent system to
William Schaut +3 more
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Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data. [PDF]
, 2020 Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours.
Abler, Daniel +13 more
core +2 more sources
Counteracting CAR T cell dysfunction [PDF]
Oncogene, 2021 AbstractIn spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure.
Mansour Poorebrahim +5 more
openaire +2 more sources
Improving CAR T-Cell Persistence [PDF]
International Journal of Molecular Sciences, 2021 Over the last decade remarkable progress has been made in enhancing the efficacy of CAR T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in hematological settings, patients that respond to CAR T therapies remain at risk of relapsing due to several factors including poor T-cell expansion and lack of long ...
Violena Pietrobon +5 more
openaire +2 more sources