Results 31 to 40 of about 293,272 (302)
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy [PDF]
, 2017 Adoptive cell therapy using chimeric antigen receptor (CAR)-engineered T cells has emerged as a very promising approach to combating cancer. Despite its ability to eliminate tumors shown in some clinical trials, CAR-T cell therapy involves some ...
Erhao Zhang, Hanmei Xu
core +6 more sources
Advanced Science, 2023 The robust and stable expression of CD38 in T‐cell acute lymphoblastic leukemia (T‐ALL) blasts makes CD38 chimeric antigen receptor (CAR)‐T/natural killer (NK) a potential therapy for T‐ALL. However, CD38 expression in normal T/NK cells causes fratricide
Chan Liao +14 more
doaj +1 more source
Impact of Manufacturing Procedures on CAR T Cell Functionality
Frontiers in Immunology, 2022 The field of chimeric antigen receptor (CAR) modified T cell therapy has rapidly expanded in the past few decades. As of today, there are six CAR T cell products that have been approved by the FDA: KYMRIAH (tisagenlecleucel, CD19 CAR T cells), YESCARTA ...
Norihiro Watanabe +3 more
doaj +1 more source
Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]
, 2018 Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B. +5 more
core +2 more sources
Myeloid conditioning with c-kit-targeted CAR-T cells enables donor stem cell engraftment [PDF]
, 2018 We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising.
Arai, Yasuyuki +9 more
core +2 more sources
Pharmacologic Control of CAR T Cells [PDF]
International Journal of Molecular Sciences, 2021 Chimeric antigen receptor (CAR) therapy is a promising modality for the treatment of advanced cancers that are otherwise incurable. During the last decade, different centers worldwide have tested the anti-CD19 CAR T cells and shown clinical benefits in the treatment of B cell tumors.
Benjamin Caulier +2 more
openaire +4 more sources
Oncogenesis, 2021 Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in the treatment of hematological malignancies.
Yaoxin Gao +14 more
doaj +1 more source
CAR-T-Zellen erkennen und eliminieren den Thyreotropin-Rezeptor exprimierende differenzierte Schilddrüsenkarzinomzellen [PDF]
, 2020 Hintergrund: Das differenzierte Schilddrüsenkarzinom weist eine sehr gute Prognose auf. Dennoch gibt es Patienten, die refraktär auf die bereits etablier-ten Therapiemöglichkeiten der operativen Therapie, der Radioiodtherapie und der dauerhaften ...
Spieker, Nicola
core +1 more source
Glycan-directed CAR-T cells [PDF]
Glycobiology, 2018 Cancer immunotherapy is rapidly advancing in the treatment of a variety of hematopoietic cancers, including pediatric acute lymphoblastic leukemia and diffuse large B cell lymphoma, with chimeric antigen receptor (CAR)-T cells. CARs are genetically encoded artificial T cell receptors that combine the antigen specificity of an antibody with the ...
Steentoft, Catharina +5 more
openaire +3 more sources
Journal of Hematology & Oncology, 2019 The current treatment for pediatric acute lymphoblastic leukemia (ALL) is highly successful with high cure rate. However, the treatment of adult ALL remains a challenge, particularly for refractory and/or relapsed (R/R) ALL.
Juanjuan Zhao, Yongping Song, Delong Liu
doaj +1 more source