Results 251 to 260 of about 11,024,988 (313)

FECH, a novel metabolic target influencing CAR T-cell phenotype and function. [PDF]

Biomark Res
Pellegrino M, Vespa S, Salvatori I, Mac GD, Valle C, Secli V, Cairoli S, Goffredo BM, Caforio M, Folgiero V, Sanvi LW, Vulpis E, Ciampini E, Scarsella M, Giorda E, Chiaradonna F, Giansanti M, Nazio F, Ferri A, Cecconi F, Campello S, Velardi E, Caruana I, de Billy E.   +23 more
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Ultrasonication-derived CAR-T vesicles preserve antigen-specific cytotoxic function. [PDF]

Front Oncol
Zmievskaya EA, Ganeeva IA, Rogov AM, Spada S, Bulatov ER.   +4 more
europepmc   +1 more source

Bound Water as a Reinforcing Element for Ultra‐Strong Polyacrylamide

Advanced Science, EarlyView.
Rather than acting as a conventional plasticizer, bound water serves as a reinforcing element in polyacrylamide by constructing strong PAM–water–PAM hydrogen‐bond networks. This water‐mediated architecture delivers ultra‐high mechanical strength and exceptional flame resistance, redefining the role of water in polymer reinforcement.
Sirawit Pruksawan, Nannan Li, Zehuang Lin, Jianwei Zheng, Terence Jun En Loh, Yi Ting Chong, Junhua Kong, Xunan Hou, Xian Jun Loh, Chaobin He, FuKe Wang   +10 more
wiley   +1 more source

Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India. [PDF]

Front Immunol
Das N, Mehta P, Gupta K, Katharia R, Pabbi S, Mishra P, Morya S.   +6 more
europepmc   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

CCL3 and IL-7 Synergistically Enhance CAR-T Efficacy in Solid Tumors. [PDF]

Adv Sci (Weinh)
Chen H, Luo X, Gao H, Ke Y, Zhan Y, Xu X, Xiong X, Wei F, Yang S, Liu Z, Yu B, Huang Z, Bian Y.   +12 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Two birds with one stone: faster, fitter CAR T cells.

Blood
Kenderian SS.
europepmc   +1 more source

Advances, challenges, and innovative strategies of CAR-T cell therapy in pancreatic cancer. [PDF]

Biomark Res
Xiao RY, Jiang YF, Zhao W, Wang QQ, Huang YQ, Li XY, Xiao YJ, Yao H, Dai RW.   +8 more
europepmc   +1 more source