Results 131 to 140 of about 812,191 (301)

Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling

Frontiers in Immunology
IntroductionChimeric antigen receptor T cell (CAR-T) therapy has shown success in treating hematological malignancies, but its effectiveness against solid tumors is hindered by T cell exhaustion.
Xuechen Yin, Wenwen Chen, Xudong Ao, Luxia Xu, Jiujiu Cao, Tinghui Huang, Junqing Liang, Jianhua Hu, Jiaqi Liu, Xinping Wang, Wenying Li, Muya Zhou, Lingfeng He, Zhigang Guo   +13 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Auto‐Generated Valence States in Electrocatalysts for Boosting Oxygen and Hydrogen Evolution Kinetics in Alkaline Water/Alkaline Seawater/Simulated Seawater/Natural Seawater

Advanced Functional Materials, EarlyView.
This review systematically highlights the latest achievements in mixed‐valence states relevant to hydrogen and oxygen evolution reactions, providing essential insights into future directions and methods for large‐scale practical implementation. This critical review is expected to provide an overview of recent advancements in diverse valence‐state metal
Jitendra N. Tiwari, Gokul Bhaskaran, Krishan Kumar, Yun Suk Huh, Young‐Kyu Han   +4 more
wiley   +1 more source

T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity

Journal for ImmunoTherapy of Cancer
Background T cells modified to express a chimeric antigen receptor (CAR) are successful against B-lineage malignancies but fail to induce durable remissions in up to half of patients and have shown limited efficacy against other types of cancer ...
M. Eric Kohler, Kole R DeGolier, Terry J Fry, Amalia M Rivera-Reyes, Jennifer M Cimons, Samuel D Burciaga, Michael C Yarnell, Amanda J Novak   +7 more
doaj   +1 more source

Anomalous Pressure‐Temperature Ultrahigh Sensitivities in Atomically Engineered Carbonitride MXenes for Multifunctional Wearable Human–Machine Interfaces: Joint Computational–Experimental Elucidations

Advanced Functional Materials, EarlyView.
Atomically engineered layered 2D Ti3CNTz carbonitride MXene exhibits ultrahigh heat and pressure sensitivity, enabling dual‐mode sensors with 300%–400% performance enhancement and durability for real‐time health‐monitoring interface devices. Precise nitrogen incorporation (e.g., Ti3C1.8N0.2Tz) boosts conductivity, enhancing temperature response, while ...
Debananda Mohapatra, Ju‐Hyoung Han, Hyun Jin Kang, Jeong Eun Byun, Seonghun Lee, Sanghyuk Lee, Yeseul Son, Jaeeun Park, Tae Joo Shin, Youngho Kang, Jung Woo Lee, Soon‐Yong Kwon, Soo‐Hyun Kim   +12 more
wiley   +1 more source

Phosphatidylserine as a tumor target for CAR-T cell therapy

Journal for ImmunoTherapy of Cancer
Background Phosphatidylserine (PS) exposed on apoptotic cells promotes immune clearance of dead cells without inducing inflammation. Conversely, PS exposure on live tumor cells promotes an immunosuppressive tumor microenvironment that hinders antitumor ...
Felipe Prosper, Sandra Hervás-Stubbs, Bruno Sangro, Juan Jose Lasarte, Noelia Casares, Teresa Lozano, Carla Castro, Mercedes Iñarrairaegui, Celia Martín-Otal, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, María Collantes, Iván Peñuelas, Alvaro Gómez-Morón, Pedro Justicia-Lirio, Felix Pareja, Isabel Vivas, Marta Larrayoz, Juan Roberto Rodriguez, Noa Martin-Cofreces   +20 more
doaj   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Application of CAR-T cells in cancer gene therapy [PDF]

, 2018
Genska terapija predstavlja obećavajući terapijski alat za liječenje onih bolesti koje se konvencionalnim metodama liječenja nisu uspješno uspijele eliminirati.
Krmpotić, Klara
core   +2 more sources

Residual‐Lithium‐to‐LiF Conversion Enables a LiF–Fluorinated Carbon Interphase for Reconstruction‐Resistant Ni‐Rich Cathodes

Advanced Functional Materials, EarlyView.
A fluorine‐rich acrylate monomer (PFHEA) was solvent‐free applied to NCM90 and thermally decomposed under Ar to convert residual lithium into LiF and form a pre‐built LiF/fluorinated amorphous carbon (LiF/FC) interphase. The LiF/FC layer suppresses NiO rock‐salt reconstruction and microcrack propagation, lowers interfacial resistance, and improves Li ...
Pangyu Kim, Juyeon Han, Junhyeok Kim, Younghoon Kim, Eunha Seo, Dain Kim, Jeeyoung Yoo   +6 more
wiley   +1 more source

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway

Cell Reports Medicine
Summary: Delivery of chimeric antigen receptors (CARs) to T cells is usually mediated by lentiviral vectors (LVs), which can have broad tropism or be T cell targeted.
Elham Adabi, Filippos T. Charitidis, Frederic B. Thalheimer, Mar Guaza-Lasheras, Colin Clarke, Christian J. Buchholz   +5 more
doaj   +1 more source