Results 141 to 150 of about 14,813,386 (261)

Phosphatidylserine as a tumor target for CAR-T cell therapy

Journal for ImmunoTherapy of Cancer
Background Phosphatidylserine (PS) exposed on apoptotic cells promotes immune clearance of dead cells without inducing inflammation. Conversely, PS exposure on live tumor cells promotes an immunosuppressive tumor microenvironment that hinders antitumor ...
Felipe Prosper, Sandra Hervás-Stubbs, Bruno Sangro, Juan Jose Lasarte, Noelia Casares, Teresa Lozano, Carla Castro, Mercedes Iñarrairaegui, Celia Martín-Otal, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, María Collantes, Iván Peñuelas, Alvaro Gómez-Morón, Pedro Justicia-Lirio, Felix Pareja, Isabel Vivas, Marta Larrayoz, Juan Roberto Rodriguez, Noa Martin-Cofreces   +20 more
doaj   +1 more source

Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High‐Density Silicon Solar Cell Arrays

Advanced Healthcare Materials, EarlyView.
In this study, we fabricate photovoltaic retinal implants with pyrolytic carbon electrodes and test their ability to stimulate mouse and pig retinas when illuminated with near‐infrared light. We find increased spiking activity in both animal models compared to spontaneous activity and TTX controls and analyze the spike amplitude, latency and frequency.
Akihiro Matsumoto, Pratik Kusumanchi, Jesper Guldsmed Madsen, Asbjørn Cortnum Jørgensen, Gisele Alves dos Reis Benatto, Sune Thorsteinsson, Peter Behrensdorff Poulsen, Keisuke Yonehara, Toke Bek, Stephan Sylvest Keller, Rasmus Schmidt Davidsen   +10 more
wiley   +1 more source

T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity

Journal for ImmunoTherapy of Cancer
Background T cells modified to express a chimeric antigen receptor (CAR) are successful against B-lineage malignancies but fail to induce durable remissions in up to half of patients and have shown limited efficacy against other types of cancer ...
M. Eric Kohler, Kole R DeGolier, Terry J Fry, Amalia M Rivera-Reyes, Jennifer M Cimons, Samuel D Burciaga, Michael C Yarnell, Amanda J Novak   +7 more
doaj   +1 more source

CAR-T Cell Therapy for Solid Tumors

Background: Chimeric antigen receptor (CAR)-modified T cells have shown remarkable results for the treatment of selected hematological malignancies, but recapitulating these results in solid cancers has been a major challenge.
Justus Weber, Tony, Liz T., Hudecek, Michael, Liz T. Tony, Andrea Stabile, Marc P. Schauer, Michael Hudecek, Schauer, Marc P., Weber, Justus, Stabile, Andrea   +9 more
core   +1 more source

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source

Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway

Cell Reports Medicine
Summary: Delivery of chimeric antigen receptors (CARs) to T cells is usually mediated by lentiviral vectors (LVs), which can have broad tropism or be T cell targeted.
Elham Adabi, Filippos T. Charitidis, Frederic B. Thalheimer, Mar Guaza-Lasheras, Colin Clarke, Christian J. Buchholz   +5 more
doaj   +1 more source

Transparent Perovskite Light‐Emitting Diodes with Conductive Oxide Top Electrodes

Advanced Materials, EarlyView.
Transparent perovskite light‐emitting diodes (TrPeLEDs) enable simultaneous display and transparency, expanding application possibilities. Using a metal oxide buffer layer and pulsed laser deposition, TrPeLEDs with diverse compositions and architectures are demonstrated.
Michele Forzatti, Sergio Martínez‐Saiz, Morena Cervino, Edoardo Stanzani, Sandra Jenatsch, Qingsen Zeng, Joo Sung Kim, Dong‐Hyeok Kim, Eojin Yoon, Tae‐Woo Lee, Daniel Tordera, Henk J. Bolink   +11 more
wiley   +1 more source

Advances in CAR-T-cell therapy in T-cell malignancies

Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet achieved comparable success in the management of
Yi Xiao, Rubing Zheng, Xiaojian Zhu
core   +1 more source

Resonant Domain Wall Dynamics in a Three‐Dimensional Magnetic Nano Double Helix

Advanced Materials, EarlyView.
3D magnetic nanostructures promise exciting possibilities for magnetization dynamics. However, experimental realizations remain scarce. In nanoprinted cobalt double helices, time‐resolved X‐ray microscopy reveals harmonic domain wall dynamics. Simulations identify the mode and additional higher‐frequency resonances, revealing a rich dynamic landscape ...
Pamela Morales‐Fernández, Iason Konstantinos‐Douveas, Claas Abert, Elina Zhakina, Sandra Ruiz‐Gómez, Claudia Fernández‐González, Luke Alexander Turnbull, Sebastian Wintz, Markus König, Simone Finizio, Markus Weigand, Naëmi Leo, Dieter Suess, Aurelio Hierro‐Rodríguez, Amalio Fernández‐Pacheco, Claire Donnelly   +15 more
wiley   +1 more source