Results 81 to 90 of about 812,191 (301)

Treating osteosarcoma with CAR T cells [PDF]

Scandinavian Journal of Immunology, 2019
AbstractNovel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop chimeric antigen receptor (CAR) targeted immunotherapy against osteosarcoma (OS).
Hakan Köksal, Elisabeth Müller, Else Marit Inderberg, Øyvind Bruland, Sébastien Wälchli   +4 more
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Investigating genetic modifications to enhance L1CAM-CAR T cell migration in solid tumors in a 3D bioprinted neuroblastoma model

Frontiers in Immunology
IntroductionEffective CAR T cell infiltration into solid tumors remains a major barrier to therapy success. Despite their clinical potential, few studies have evaluated phenotypes of CAR T cells successfully invading the tumor mass following infusion ...
Lena Andersch, Lena Andersch, Lena Andersch, Laura Grunewald, Laura Grunewald, Maria Stecklum, Filippos Klironomos, Kerstin Haase, Viola Hollek, Viola Hollek, Tobias Lam, Beate Anahita Jung, Anika Winkler, Silke Schwiebert, Kathy Astrahantseff, Michael Launspach, Marvin Jens, Anton Henssen, Lutz Kloke, Nils Blüthgen, Nils Blüthgen, Angelika Eggert, Johannes H. Schulte, Kathleen Anders, Annette Künkele, Annette Künkele   +25 more
doaj   +1 more source

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. [PDF]

, 2018
One major hurdle to the success of adoptive T-cell therapy is the identification of antigens that permit effective targeting of tumors in the absence of toxicities to essential organs.
Abraham, Tara S., Baybutt, Trevor R., Flickinger, John C., Hersperger, Adam R., Magee, Michael S., Marszalowicz, Glen P, Prajapati, Priyanka, Ridge, Natalie A., Snook, Adam E., Waldman, Scott A.   +9 more
core   +1 more source

Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity [PDF]

, 2015
Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. Here,
Borsheim, Bowman, Carmel McConville, Carmela De Santo, Francis Mussai, Gavin Bendle, Hannah Webber, John Anderson, Jonathan Fisher, Kate Wheeler, Kevin Petrie, Lin, Liu, Lofberg, Louis Chesler, Morris, Morris, Mujoo, Pistoia, Rachel Wheat, Rodolfo, Rodolfo, Serafini, Sharon Egan, Stuart Hunter, Yordan Sbirkov   +25 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies

Experimental Hematology & Oncology
Relapsed/refractory T cell-derived malignancies present with high heterogeneity and poor prognoses. Recently, chimeric antigen receptor (CAR)-T cell therapy has shown remarkable safety and efficacy in the treatment of B cell-derived malignancies. However,
Haiqiong Zheng, Houli Zhao, Shi Han, Delin Kong, Qiqi Zhang, Mingming Zhang, Yijin Chen, Meng Zhang, Yongxian Hu, He Huang   +9 more
doaj   +1 more source

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors

Journal for ImmunoTherapy of Cancer
Background Responsiveness to chimeric antigen receptor (CAR) T cell therapy correlates with CAR T cell expansion and persistence in vivo. Multiple strategies improve persistence by increasing stem-like properties or sustaining CAR T cell activity with ...
Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm   +9 more
doaj   +1 more source

Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells [PDF]

, 2016
The success of adoptive T-cell therapies for the treatment of cancer patients depends on transferred T-lymphocytes finding and infiltrating cancerous tissues.
Ager, Elizabeth, Mohammed, Rebar N., Watson, Heulwen Angharad, Wehenkel, Sophie C.   +3 more
core   +2 more sources