Results 161 to 170 of about 16,658,609 (280)

Pediatric AML CAR T cell therapy. [PDF]

Mol Ther Oncol
Bhagwat AS, Naik S.
europepmc   +1 more source

Outcomes of point-of-care manufactured CAR T cell therapy for B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma in Vietnam

Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of relapsed/refractory (R/R) B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL), but access remains limited in resource-constrained settings.
Dao, Lan T.M., Nguyen, Hoang - Phuong, Hermiston, Michelle L., Mai, Hien T., Phan, Trang Thi Kieu, Phan, Quynh Lan, Nguyen, Ngoc Quang, Mai, Lan, Dao, Hong-Nhung, Pham, Trang H., Pham, Viet Huong T., Le, Van Binh, Bach, Quoc Khanh, Nguyen, Quoc Nhat, Phung, Nam Lam, Nguyen, Liem Thanh, Pham, Phuong T., Nguyen, Thanh Mai T., Hoang, Van T., Nguyen, Do Quang Trung, Nguyen, Duy D.   +20 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Quality of Life in CAR-T Cell Therapy. [PDF]

Hematol Rep
Alati C, Pitea M, Porto G, Policastro G, Bilardi E, Utano G, Giordano L, Sgarlata A, Delfino IM, Idato A, Santoro G, Canale FA, Naso V, Martino M.   +13 more
europepmc   +1 more source

T cell malignancies after CAR T cell therapy in the DESCAR-T registry

International audienceThe risk of T cell malignancies after chimeric antigen receptor (CAR) T cell therapy is a concern, although the true incidence remains unclear.
Todesco, Eve, Bachy, Emmanuel, Guiraud, Vincent, Houot, Roch, Thieblemont, Catherine, Barete, Stephane, Le Gouill, Steven, Choquet, Sylvain, Bay, Jacques-Olivier, Baruchel, André, Boissel, Nicolas, Arnulf, Bertrand, Duléry, Rémy   +12 more
core   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

The Conflicting Role of Myeloid Cells in CAR T-Cell Therapy. [PDF]

Cancer Res
DeFranco G, Siegler EL, Kenderian SS.
europepmc   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Bispecific ANXA2/CD147 CAR-T cell therapy for osteosarcoma. [PDF]

Oncogene
Tang HJ, Dai W, Xiao DT, Li HN, Xiong L, Yang MX, Liang JM, Zou Z, Mai L, Li SH, Liu SY, Feng WY, Lin YH, He ML, Zhan XL, Liu Y.   +15 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source