Results 81 to 90 of about 16,658,609 (280)

Analysis and Augmentation of the Immunologic Bystander Effects of CAR T Cell Therapy in a Syngeneic Mouse Cancer Model.

, 2020
The therapeutic efficacy of adoptive transfer of T cells transduced with chimeric antigen receptors (CARs) has been limited in the treatment of solid cancers, partly due to tumor antigen heterogeneity.
Arguiri, E, Leibowitz, MS, Klampatsa, A, Liousia, M, Albelda, SM, Sun, J   +5 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies

, 2023
Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, the development of CAR-T-cell therapy for T-cell malignancies is in its nascent stage.
Chikao Morimoto, Nam H. Dang, Taketo Yamada, Tsutomu Sato, Akinori Wada, Yoshihiro Hayakawa, Ryo Hatano, Tatsuhiko Ozawa, Takeshi Susukida, Eiji Kobayashi, Miho Arai, Shohei Kikuchi, Yuichi Adachi, Hiroyuki Kishi, Noriaki Iwao, Yusuke Kamihara   +15 more
core   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source

CAR T-cell therapy in autoimmune diseases: a promising frontier on the horizon

Frontiers in Immunology
Although current treatments for autoimmune diseases can effectively control symptoms, they rarely lead to cures and often require lifelong use, accompanied by considerable adverse effects.
Dehong Wu, Dehong Wu, Zijun Y. Xu-Monette, Jia Zhou, Kepeng Yang, Xinchang Wang, Yongsheng Fan, Ken H. Young, Ken H. Young   +8 more
doaj   +1 more source

CAR-T-Cell Therapy for Solid Tumors Positive for Fibronectin Extra Domain B

, 2022
(1) Background: The lack of specific targets has slowed the progress of CAR-T in treating solid tumors. Recent studies have revealed that EDB-FN (fibronectin extra domain B) may be an effective target for CAR-T treatment of solid tumors; EDB-FN is ...
Chang Liu, Zhe Yang, Zhijie Zhang, Hongping Yin, Yang, Zhe, Yin, Hongping, Zhang, Zhijie, Liu, Chang   +7 more
core   +1 more source

Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity

Arthritis Care &Research, EarlyView.
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley   +1 more source

CAR-T Cell Therapy for Follicular Lymphomas.

Mediterranean journal of hematology and infectious diseases
Follicular lymphoma is the second most diagnosed lymphoma in Western Europe. Significant advancements have considerably improved the survival of FL patients. However, 10-20% of these patients are refractory to standard treatments, and most of them will relapse.
Testa U., D'Alo' F., Pelosi E., Castelli G., Leone G.   +4 more
openaire   +3 more sources

CAR Informe anual 1983

, 1983
Le ha correspondido, a la corporación CAR, durante este tiempo una etapa particularmente dinámica e interesante. La Corporación había venido consolidándose como entidad líder en la región y modelo de entidades similares.
Corporación Autónoma Regional de Cundinamarca – CAR
core  

CAR-T therapy: from anti-cancer therapy to new potential uses in heart fibrosis

, 2022
openCon l’acronimo “CAR-T therapy” (“Chimeric Antigen Receptor T cell therapy” ovvero “Terapia a base di cellule T esprimenti un Recettore Chimerico per l’Antigene”) si indicano le nuove terapie avanzate, personalizzate, contro il cancro che agiscono ...
RAISA, RICCARDO
core