Results 91 to 100 of about 21,080,479 (286)

THE EVOLUTION OF CAR T-CELL THERAPY: ETHICS AND EFFICIENCY

, 2022
Engineering T cells with a chimeric antigen receptor (CAR) that reprograms their antigen selectivity and signalling has recently emerged as one of the most promising therapeutic approaches for treating cancers.
Sara Khemani, Jumana Badar
core   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

CAR T-cell therapy in autoimmune diseases: a promising frontier on the horizon

Frontiers in Immunology
Although current treatments for autoimmune diseases can effectively control symptoms, they rarely lead to cures and often require lifelong use, accompanied by considerable adverse effects.
Dehong Wu, Dehong Wu, Zijun Y. Xu-Monette, Jia Zhou, Kepeng Yang, Xinchang Wang, Yongsheng Fan, Ken H. Young, Ken H. Young   +8 more
doaj   +1 more source

CAR-T Cell Therapy for Follicular Lymphomas.

Mediterranean journal of hematology and infectious diseases
Follicular lymphoma is the second most diagnosed lymphoma in Western Europe. Significant advancements have considerably improved the survival of FL patients. However, 10-20% of these patients are refractory to standard treatments, and most of them will relapse.
Testa U., D'Alo' F., Pelosi E., Castelli G., Leone G.   +4 more
openaire   +3 more sources

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

The efficacy and safety of CD7 chimeric antigen receptor T-cell therapy for hematologic malignancies: a systematic review and meta-analysis

Frontiers in Oncology
IntroductionCD7 chimeric antigen receptor T-cell (CAR-T cell) therapy is an emerging method for treating hematological malignancies, and is another breakthrough in CAR-T cell therapy.MethodsThis study summarizes the currently published clinical research ...
Jile Liu, Yuxin An, Rui Sun, Xiaomei Zhang, Shujing Guo, Xuejin Gao, Mingfeng Zhao   +6 more
doaj   +1 more source

Communication About Chimeric Antigen Receptor T-Cell (CAR-T) Therapy

•Chimeric antigen receptor therapy yields hope and uncertainty for cancer patients.•Oncologists discuss the novelty, efficacy, and risks of this therapy with patients.•Oncologists rarely raise the issue of treatment failure or advanced care planning ...
Amonoo, Hermioni L., Traeger, Lara, Holmbeck, Katherine, El-Jawahri, Areej, Lavoie, Mitchell W., Johnson, P. Connor, Barata, Anna, Dhawale, Tejaswini, Nelson, Ashley M., Nabily, Anisa, Choe, Joanna, Tripathi, Astha, Frigault, Matt, Boateng, Kofi   +13 more
core   +1 more source

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Application of Nanotechnology in CAR-T-based Cancer Therapy

Shengwu huaxue yu shengwu wuli jinzhan
Chimeric antigen receptor T (CAR-T) cell therapy is an innovative and cutting-edge treatment in the field of adoptive cell therapy. It represents an important milestone in personalized and precision medicine.
XU Lin, HU Bo, ZHENG Lu-Lu, JIANG Shao-Ping, RUAN Shao-Bo, HUANG Yuan-Yu   +5 more
doaj   +1 more source