Results 41 to 50 of about 856,598 (307)

Study of Dynamics of Corrosive Wear of Load-Bearing Metal Structures of Subway Cars with Expired Service Life

Applied Sciences
The present study focuses on scientific and experimental research on corrosion damage to the bodies of subway cars. The main purpose of the research is to assess the degree of corrosive wear on the main load-bearing metal structures of the subway cars ...
Andrii Sulym, Yurii Pavlenko, Dmytro Fedosov-Nikonov, Tetiana Popova, Ján Dižo, Miroslav Blatnický   +5 more
doaj   +1 more source

Determinants of car ownership in rural and urban areas: a pseudo-panel analysis [PDF]

This paper examines the factors determining car ownership for households living in rural and urban areas. A dynamic car ownership model is estimated using a pseudo-panel approach, based on data from Family Expenditure Surveys in the UK for 1982 to 1995 ...
Dargay, J.
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

THE IMPROVEMENT OF THE ROLLING STOCK DESIGN FOR CONTAINERS TRANSPORTATION

Nauka ta progres transportu, 2009
In relation to development of container transportations the demand on the specialized rolling stock best adjusted for transportation of containers is sharply increased.
V. M. Bubnov, S. V. Myamlin, N. L. Hurzhy   +2 more
doaj  

The determination of the rolling resistance coefficient of a passenger vehicle with the use of roller test bench method

MATEC Web of Conferences, 2019
Contemporary vehicle are designer to be eco-friendly. One of the factors limiting the energy consumption of driving processes is a low value of the rolling resistance coefficient.
Pałasz Bartłomiej, Waluś Konrad J., Warguła Łukasz   +2 more
doaj   +1 more source

Car Sharing and Peak Spreading Studies in Sheffield: Final Report. [PDF]

, 1981
This Study of two firms in Sheffield city centre has been carried out under a contract with LTR2 Division of the Department of Transport, dated 28th March 1980.
May, A.D., Montgomery, F.O., Wheatley, M.D.   +2 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source