Results 121 to 130 of about 8,575 (176)

Pharmacological Studies on N-Demethylated Carbachol

Journal of Pharmaceutical Sciences, 1978
In attempts to find a drug more active than pilocarpine, the tertiary nitrogen derivative of carbachol, N-demethylated carbachol, was synthetized and tested on several autonomic nervous system preparations. N-Demethylated carbachol was active at muscarinic and nicotinic sites in vivo and in vitro.
C Y Chiou
exaly   +3 more sources

Carbachol in Cataract Surgery

Archives of Ophthalmology, 1968
Carbachol in a weak dilution (0.01%) is effective and relatively nonirritating when used as a miotic after the lens is removed in round pupil cataract extraction.
H, Beasley, A R, Borgmann, T O, McDonald, P R, Belluscio   +3 more
openaire   +2 more sources

Learned aversions to intracerebral carbachol

Physiology & Behavior, 1977
Abstract The learned taste aversion paradigm was employed to test for aversive effects of microinjections of carbachol to the medial septum, lateral ventricle and ventral hippocampus. To determine the locus of action of carbachol, either a central cholinergic blocker (atropine sulfate) or a peripheral cholinergic blocker (atropine methyl nitrate) was
R H, Myers, J M, De Castro
openaire   +2 more sources

Comparison of intraocular acetylcholine and carbachol

Journal of Cataract and Refractive Surgery, 1986
Commercially available 1% acetylcholine chloride and 0.01% carbachol chloride, which are commonly used as miotics in intraocular surgery, have recently been reformulated. Comparative studies of these agents show similar miotic activity. However, in vitro perfusion of human corneas demonstrated that 1% acetylcholine chloride causes marked changes in ...
R W, Yee, H F, Edelhauser
openaire   +2 more sources

Determination of Carbachol in Aqueous Solution

Journal of Pharmaceutical Sciences, 1969
A more specific method of analysis of carbachol (carbamylcholine chloride) in aqueous solution is reported. The procedure requires the chlorination of the free N—H moiety which in turn is utilized to oxidize iodide to iodine. Quantitation is then accomplished by reacting this latter product with starch and measuring the resultant blue color.
R, Puckett, R D, Poe
openaire   +2 more sources

Carbachol effects on hippocampal neurons in vitro: dependence on the rate of rise of carbachol tissue concentration

Experimental Brain Research, 1988
Nominally K-sensitive microelectrodes were used to measure carbachol (CCh) in order to study the dependence of muscarinic effects on CCh concentration and exposure time in guinea pig hippocampal slices. Interference presumably originating from tissue choline-compounds was neutralized by pre-equilibration of the slices with 500 microM choline and ...
W, Müller, U, Misgeld, U, Heinemann
openaire   +2 more sources

Central hyperglycaemic effect of adrenaline and carbachol

Acta Endocrinologica, 1985
Abstract. The effect of chemical stimulation of the brain on glucoregulation was studied in anaesthetized rats. Adrenaline, noradrenaline, acetylcholine, dopamine and carbachol (5 × 10−8 mol/μl saline) were injected directly into the third cerebral ventricle and changes in hepatic venous plasma glucose, immunoreactive glucagon and insulin ...
A, Iguchi, H, Matsunaga, M, Gotoh, T, Nomura, A, Yatomi, N, Sakamoto   +5 more
openaire   +2 more sources

Effect of Carbachol on Rabbit Corneal Endothelium

Archives of Ophthalmology, 1987
We investigated the current reformulation of the commercially available intraocular preparation of carbachol for its effect on corneal thickness and endothelial cell ultrastructure. A 15-minute perfusion in the specular microscope with 0.01% carbachol caused a significant increase in the corneal swelling rate, which returned to control values after 75 ...
D B, Birnbaum, D S, Hull, K, Green, N P, Frey   +3 more
openaire   +2 more sources

The subfornical organ and carbachol-induced drinking

Brain Research, 1972
Summary The initial report of Routtenberg and Simpson 32 indicated that exogenous carbamylcholine chloride (carbachol) applied directly to 3rd ventricle or subfornical organ elicited drinking behavior. The possibility that subfornical organ was the site of action of the carbachol was more thoroughly investigated in this study.
J B, Simpson, A, Routtenberg
openaire   +2 more sources

Pre- and postjunctional neuromuscular blockade by carbachol

Naunyn-Schmiedeberg's Archives of Pharmacology, 1975
Carbachol, when applied to the bathing Ringer solution of frog sartorius muscles, caused depolarization of the endplate and a blockade of endplate potentials (EPP's), miniature EPP's (mepp's) and the iontophoretic acetylcholine potential. In muscles treated with an analog of hemicholinium-3, alpha, alpha'bis(dimethylammonium acetaldehyde diethylacetal)-
R L, Volle, E G, Henderson
openaire   +2 more sources