Results 111 to 120 of about 120,317 (381)

Epilepsy control with carbamazepine monotherapy from a genetic perspective

BMC Pharmacology and Toxicology, 2018
Background Ethnicity variation is one of the main factors that may affect drug response in clinical practice. As MTHFR gene affects different transcriptome and proteome which affect the clinical response of drugs.
Shakir Ullah, Niaz Ali, Adnan Khan, Saad Ali, Haleema Rehna Nazish, Zia Uddin   +5 more
doaj   +1 more source

Expanding the Phenotype of CYFIP2‐Related Developmental Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Pathogenic CYFIP2 variants cause developmental and epileptic encephalopathy (DEE), characterized by early‐onset intractable epilepsy and developmental delay. The disease course has not been delineated. Codon Arg87 is a de novo mutational hotspot associated with a severe DEE phenotype via gain‐of‐function mechanisms. Currently, there
Michaela Squire, Jenna K. Lea, Zheng (Jane) Fan, Senyene E. Hunter   +3 more
wiley   +1 more source

Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria

Journal of Central Nervous System Disease, 2020
Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate).
Unyime Israel Eshiet, Chukwuemeka Michael Ubaka, Chinwe Victoria Ukwe   +2 more
doaj   +1 more source

Insights Into Patient‐Level Exposure to Actionable Pharmacogenomic Medications in Australia Using a New National Pharmacogenomic Guideline

Clinical Pharmacology &Therapeutics, EarlyView.
This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni, Chin Hang Yiu, Mohammad A. Ali, Christine Y. Lu   +3 more
wiley   +1 more source

Simultaneous Determination of Carbamazepine and Carbamazepine-10,11-epoxide in Different Biological Matrices by LC-MS/MS

Journal of Interdisciplinary Medicine, 2017
An uncomplicated, sensitive liquid chromatography linked to mass spectrometry (LC/MS) for evaluation of carbamazepine and carbamazepine-10,11-epoxide (its metabolite) in human plasma, human saliva, rat plasma, and rabbit plasma was developed.
Andonie Dan, Gáll Zsolt, Bosa Paul, Dogaru Maria Titica, Vancea Szende   +4 more
doaj   +1 more source

Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]

, 2003
Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
core   +1 more source

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko, Catherine M.K.E. de Cuba, Annika A. de Goede, Titiaan E. Post, Roman Bohoslavsky, Pamela K. Strugala, Jules A.A.C. Heuberger, Geert Jan Groeneveld   +7 more
wiley   +1 more source

Purslane protects against the reproductive toxicity of carbamazepine treatment in pilocarpine-induced epilepsy model

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To investigate the protective effect of purslane with carbamazepine treatment. Methods: Male albino rats were modulated by pilocarpine to be epileptic.
Widad Makhdour Al-Bishri, Eman Salah Abdel-Reheim, Amr Reda Zaki   +2 more
doaj   +1 more source

The impact of carbamazepine crystallinity on carbamazepine-loaded microparticle formulations

, 2021
Saeid Mezail Mawazi, Abd Almonem Doolaanea, Hazrina Ab. Hadi, Bappaditya Chatterjee   +3 more
openalex   +2 more sources

Extracorporeal treatment for carbamazepine poisoning: Systematic review and recommendations from the EXTRIP workgroup

Clinical toxicology, 2014
Context. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup was created to provide evidence and consensus-based recommendations on the use of extracorporeal treatments (ECTRs) in poisoning. Objectives.
M. Ghannoum, C. Yates, T. Galvão, K. Sowinski, Thị Hải Vân Võ, A. Coogan, S. Gosselin, V. Lavergne, T. Nolin, R. Hoffman   +9 more
semanticscholar   +1 more source