Results 111 to 120 of about 118,649 (387)

Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS

Регуляторные исследования и экспертиза лекарственных средств, 2018
Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use ...
T. A. Rodina, E. S. Melnikov, A. V. Sokolov, A. B. Prokofiev, V. V. Arkhipov, G. V. Adamov, D. L. Pozdnyakov, Yu. V. Olefir   +7 more
doaj  

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z [PDF]

, 2019
The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals.
Andrew S. Chu (6256490), David H. Perlmutter (154778), Gary A. Silverman (154780), Ivet Bahar (22505), Jie Li (15030), Michael Ewing (518331), Murat C. Cobanoglu (6256487), Pamela Hale (518329), Radhika Muzumdar (6256496), Stephen C. Pak (154777), Tunda Hidvegi (518328), Yan Wang (15435), Zhenwei Gong (6256493)   +12 more
core   +3 more sources

Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus

Epileptic Disorders, EarlyView.
Abstract This case study reports the first documented use of stereoelectroencephalography (SEEG)‐guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33‐year‐old woman with drug‐resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone.
Odile Feys, Julia Makhalova, Thomas Manners, José‐David Herrera‐García, Romain Carron, Fabrice Bartolomei   +5 more
wiley   +1 more source

Protective Effect of Wheat Germ Oil on Sex Hormones Disorders and Uterine Tissue Disorders Morphology Following Treatment with Carbamazepine in Epileptic Female Mice with Pentylenetetrazol [PDF]

Journal of Advanced Biomedical Sciences, 2015
Background & Objective: Epilepsy is one of the common neurological diseases and carbamazepine is an antiepileptic drug that causes oxidative stress, endocrine and the reproductive system long term disorders.
Elham Ahmadi, Vahid Nejati, Gholamreza Najafi, Shiva Khezri   +3 more
doaj  

The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]

, 2014
The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi, Barzegar-Jalali M, Clegg DO, Ford JL, Hiba Al-Hamidi, Horton D, Kofi Asare-Addo, Mike Kitson, Sandip Desai   +8 more
core   +1 more source

Unmet needs of women with epilepsy living in rural low‐ and middle‐income countries: The experience of the Bolivian Chaco

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 70 million people worldwide, with 80% living in low‐ and middle‐income countries (LMICs), where many people with epilepsy (PWE) go undiagnosed or untreated. Over the last few decades, many efforts have been made worldwide to reduce the treatment gap (TG) in LMICs.
Alessandra Nicoletti, Gianluca Latino, Calogero Edoardo Cicero, Anna Barbiero, Chiara Aguzzoli, Bianca Ribelli, Valentina Petrini, Maria Micieli, Sandra Padilla, Estela Vilte, Francesco Cosmi, Elizabeth Blanca Crespo Gomez, Alessandro Bartoloni, Loretta Giuliano   +13 more
wiley   +1 more source

Epilepsy control with carbamazepine monotherapy from a genetic perspective

BMC Pharmacology and Toxicology, 2018
Background Ethnicity variation is one of the main factors that may affect drug response in clinical practice. As MTHFR gene affects different transcriptome and proteome which affect the clinical response of drugs.
Shakir Ullah, Niaz Ali, Adnan Khan, Saad Ali, Haleema Rehna Nazish, Zia Uddin   +5 more
doaj   +1 more source

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source

Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria

Journal of Central Nervous System Disease, 2020
Background: Carbamazepine and valproate are widely used in the treatment of epileptic seizures. However, these agents exhibit certain adverse effects including hematopoietic disorders (carbamazepine) and severe hepatotoxicity (valproate).
Unyime Israel Eshiet, Chukwuemeka Michael Ubaka, Chinwe Victoria Ukwe   +2 more
doaj   +1 more source