Results 111 to 120 of about 77,203 (291)

Contaminants of emerging concern in agricultural soils: Current understanding, overlooked issues, and future priorities

PLANTS, PEOPLE, PLANET, EarlyView.
Contaminants of emerging concern (CECs) in agriculture represent a growing global challenge for food safety and public health. In this review, we synthesized evidence on how substances such as pharmaceuticals, microplastics, and per‐ and polyfluoroalkyl substances (PFAS) enter soils, accumulate in crops, and affect ecological and human health. We found
Laura J. Carter, Evyatar Ben Mordechay, Benny Chefetz, Zeyou Chen, Xinyi Cui, Jay Gan, Hui Li, Audrey Moores, Xiaoyu Gao   +8 more
wiley   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short‐Chain Fatty Acids

Phytotherapy Research, EarlyView.
Baicalin restores the hypoglycemic effect of metformin by decreasing the serum imidazole propionate. ABSTRACT Gut microbiota dysbiosis is implicated in metformin non‐response. This study aimed to investigate whether baicalin, a microbiota‐modulating flavonoid derived from Radix Scutellariae, could restore metformin sensitivity and explored the ...
Aiting Wang, Zenghui Miao, Bangrong Huang, Jiayu Zeng, Mingxia Yuan, Dan Yan   +5 more
wiley   +1 more source

NEW METHODS OF OPTIMIZATION OF EPILEPSY PHARMACOTHERAPY: USE OF BAYESIAN PHARMACOKINETIC MODELING

Эпилепсия и пароксизмальные состояния, 2016
There was carried out the therapeutic drug monitoring of antiepileptic drug carbamazepine by use of a bayesian mathematical modeling method in 47 patients with a focal epilepsy.
Z. А. Suslina, А. K. Sariev, D. А. Аbaimov, T. YU. Noskova, R. D. Sejfulla, V. V. Shvedkov, D. I. Prokhorov, M. V. Shiryaeva, L. А. Mota   +8 more
doaj  

Surface Sulfate Modification Promoted Excitons Extraction of BiOBr Nanosheets for Efficient 1O2 Photosynthesis and Chlorophenols Dechlorination

Rare Metals, EarlyView.
ABSTRACT Photocatalytic molecular oxygen (O2) activation provides a sustainable approach to produce singlet oxygen (1O2) for organic contaminants detoxification. However, the charge carriers‐involved pathway usually suffers from unsatisfactory 1O2 production efficiency owing to energy loss caused by photogenerated hole‐mediated superoxide species (•O2−
Yan‐Biao Shi, Zhi‐Ping Yang, Chen‐Chen Zhang, Pin‐Ji Chen, Hao‐Yang Fu, Xu‐Peng Liu, Hao Li, Bo Lai, Li‐Zhi Zhang   +8 more
wiley   +1 more source

Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy

Epilepsia Open
Objective Carbamazepine is the first line treatment for patients affected by KCNQ2 developmental and epileptic encephalopathy. It is efficient to reduce or stop seizures in this context.
Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard   +7 more
doaj   +1 more source

The impact of carbamazepine crystallinity on carbamazepine-loaded microparticle formulations

, 2021
Saeid Mezail Mawazi, Abd Almonem Doolaanea, Hazrina Ab. Hadi, Bappaditya Chatterjee   +3 more
openalex   +2 more sources

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): baseline data from day surgery practice in the UK

Anaesthesia, EarlyView.
Summary Introduction Most patients undergoing elective surgery in the UK are discharged from hospital on the same day. Despite this, there is a lack of UK patient‐centred outcome measures relating to quality of recovery, pain and analgesic use. The POPPY study was a UK‐wide prospective, observational study measuring short‐ and longer‐term patient ...
Martha Belete, Adam B. Brayne, Harriet Daykin, Matthew Everson, William M. Hare, Anna Ratcliffe, Lexy Sorrell, Mark Rockett, on behalf of the Research and Audit Federation of Trainees   +8 more
wiley   +1 more source

Crystal polymorphism in a carbamazepine derivative: Oxcarbazepine

, 2009
Katie M. Lutker, Adam J. Matzger
openalex   +2 more sources

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source